Curvature-mediated rapid extravasation and penetration of nanoparticles against interstitial fluid pressure for improved drug delivery.

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作者： Xiaohe,Jiang ^[1] ; Sai,Xu ^[2] ; Yunqiu,Miao ^[3] ; Kang,Huang ^[2] ; Bingqi,Wang ^[1] ; Bingwen,Ding ^[1] ; Zhuan,Zhang ^[4] ; Zitong,Zhao ^[5] ; Xinxin,Zhang ^[3] ; Xinghua,Shi ^[2] ; Miaorong,Yu ^[1] ; Falin,Tian ^[2] ; Yong,Gan ^[6]

作者单位： State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;University of Chinese Academy of Sciences, Beijing 100049, China. ^[1] University of Chinese Academy of Sciences, Beijing 100049, China.;Chinese Academy of Sciences Center for Excellence in Nanoscience National Center for Nanoscience and Technology, Beijing 100190, China. ^[2] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[3] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China. ^[4] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;School of Pharmacy, Henan University, Kaifeng 475004, China. ^[5] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;University of Chinese Academy of Sciences, Beijing 100049, China.;National Medical Products Administration Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, National Institutes for Food and Drug Control, Beijing 100050, China. ^[6]

关键词 curvature extravasation interstitial fluid pressure nanoparticles penetration