Massively parallel in vivo Perturb-seq reveals cell-type-specific transcriptional networks in cortical development.

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作者： Xinhe,Zheng ^[1] ; Boli,Wu ^[1] ; Yuejia,Liu ^[1] ; Sean K,Simmons ^[2] ; Kwanho,Kim ^[2] ; Grace S,Clarke ^[1] ; Abdullah,Ashiq ^[1] ; Joshua,Park ^[1] ; Jiwen,Li ^[1] ; Zhilin,Wang ^[1] ; Liqi,Tong ^[3] ; Qizhao,Wang ^[3] ; Keerthi T,Rajamani ^[4] ; Rodrigo,Muñoz-Castañeda ^[4] ; Shang,Mu ^[4] ; Tianbo,Qi ^[1] ; Yunxiao,Zhang ^[1] ; Zi Chao,Ngiam ^[5] ; Naoto,Ohte ^[5] ; Carina,Hanashima ^[5] ; Zhuhao,Wu ^[4] ; Xiangmin,Xu ^[3] ; Joshua Z,Levin ^[2] ; Xin,Jin ^[6]

作者单位： Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA 92037, USA. ^[1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. ^[2] Center for Neural Circuit Mapping, Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92617, USA. ^[3] Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10021, USA. ^[4] Center for Advanced Biomedical Sciences, Waseda University, Tokyo 162-8480, Japan. ^[5] Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA 92037, USA. Electronic address: xinjin@scripps.edu. ^[6]

关键词 AAV vectors CRISPR screen brain development corticogenesis in vivo Perturb-seq single cell genomics