首页> European journal of medicinal chemistry> Discovery of novel small molecules targeting the USP21/JAK2/STAT3 axis for the treatment of triple-negative breast cancer.

Discovery of novel small molecules targeting the USP21/JAK2/STAT3 axis for the treatment of triple-negative breast cancer.

导出 LinkOut

翻译打印收藏纠错

第一作者： Lin,Long

第一单位： The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, 421001, China.

作者： Lin,Long ^[1] ; Jiachi,Xu ^[2] ; Xiaowen,Qi ^[3] ; Yan,Pen ^[4] ; Chengkun,Wang ^[5] ; Weifan,Jiang ^[4] ; Xue,Peng ^[4] ; Zecheng,Hu ^[3] ; Wenjun,Yi ^[6] ; Liming,Xie ^[7] ; Xiaoyong,Lei ^[8] ; Zhen,Wang ^[9] ; Linsheng,Zhuo ^[10]

作者单位： The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, 421001, China. ^[1] The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China; Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, 410011, China. ^[2] The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China. ^[3] School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, 421001, China. ^[4] Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, 421001, China. ^[5] Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, 410011, China. ^[6] The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China. Electronic address: xieliming2019@usc.edu.cn. ^[7] The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, 421001, China. Electronic address: leix_yong@163.com. ^[8] The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, 421001, China; National Health Commission Key Laboratory of Birth Defect Research and Prevention Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan 410008, China. Electronic address: zhenw@usc.edu.cn. ^[9] The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, 421001, China; National Health Commission Key Laboratory of Birth Defect Research and Prevention Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan 410008, China. Electronic address: lszhuo@usc.edu.cn. ^[10]

关键词 JAK2 STAT3 Triple-negative breast cancer USP21 Ubiquitination