Potent human monoclonal antibodies targeting Epstein-Barr virus gp42 reveal vulnerable sites for virus infection.

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作者： Ge-Xin,Zhao ^[1] ; Xin-Yan,Fang ^[2] ; Guo-Long,Bu ^[1] ; Shuai-Jia-Bin,Chen ^[2] ; Cong,Sun ^[1] ; Ting,Li ^[1] ; Chu,Xie ^[1] ; Yu,Wang ^[1] ; Shu-Xin,Li ^[1] ; Ning,Meng ^[1] ; Guo-Kai,Feng ^[1] ; Qian,Zhong ^[1] ; Xiang-Wei,Kong ^[3] ; Zheng,Liu ^[4] ; Mu-Sheng,Zeng ^[5]

作者单位： State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. ^[1] Cryo-electron Microscopy Center, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China; Department of Chemical Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China. ^[2] State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China; Department of Otorhinolaryngology, Sun Yat-sen Memorial Hospital, Guangzhou, China. Electronic address: kongxw8@mail.sysu.edu.cn. ^[3] Cryo-electron Microscopy Center, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China. Electronic address: liuz3@sustech.edu.cn. ^[4] State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. Electronic address: zengmsh@sysucc.org.cn. ^[5]

关键词 Epstein-Barr virus epitope fusion machinery gp42 human neutralizing antibody monoclonal antibody sites of vulnerability vaccine

主题词人类(Humans);疱疹病毒4型, 人(Herpesvirus 4, Human);爱泼斯坦巴尔病毒感染(Epstein-Barr Virus Infections);抗体, 单克隆(Antibodies, Monoclonal);表位(Epitopes);动物(Animals);抗体, 中和(Antibodies, Neutralizing);抗体, 病毒(Antibodies, Viral);小鼠(Mice);组织相容性抗原Ⅱ类(Histocompatibility Antigens Class II);病毒蛋白质类(Viral Proteins);B-淋巴细胞(B-Lymphocytes)

DOI 10.1016/j.xcrm.2024.101573

PMID 38776874

发布时间 2024-06-07

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Cell reports. Medicine

2024年5卷5期

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Potent human monoclonal antibodies targeting Epstein-Barr virus gp42 reveal vulnerable sites for virus infection.

Cell reports. Medicine

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Potent human monoclonal antibodies targeting Epstein-Barr virus gp42 reveal vulnerable sites for virus infection.

Cell reports. Medicine

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Cell reports. Medicine

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