Effects of hypromellose acetate succinate on recrystallization inhibition, miscibility, and dissolution enhancement of baloxavir marboxil solid dispersions.

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作者： Lili,Wang ^[1] ; Hengqian,Wu ^[2] ; Zhengping,Wang ^[3] ; Zhuang,Ding ^[3] ; Yanna,Zhao ^[3] ; Suye,Li ^[4] ; Heng,Zhang ^[2] ; Guangwei,Jia ^[5] ; Lingfeng,Gao ^[2] ; Jun,Han ^[6]

作者单位： School of Chemistry and Chemical Engineering, University of Jinan, Jinan, Shandong 250022, China; Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng, Shandong 252000, China. ^[1] School of Chemistry and Chemical Engineering, University of Jinan, Jinan, Shandong 250022, China. ^[2] Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng, Shandong 252000, China. ^[3] Institute of Pharmaceutical Research, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China. ^[4] Key Laboratory of Clinical Pharmacology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, China. ^[5] School of Chemistry and Chemical Engineering, University of Jinan, Jinan, Shandong 250022, China; Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng, Shandong 252000, China. Electronic address: junhanmail@163.com. ^[6]

关键词 Hypromellose acetate succinate Miscibility Solid dispersion

主题词结晶(Crystallization);溶解度(Solubility);聚合物(Polymers);吡啶酮类(Pyridones)

DOI 10.1016/j.ijbiomac.2024.132050

PMID 38777690

发布时间 2024-05-29

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