KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy.

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第一作者： Capucine,de Talhouët

第一单位： Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.

作者： Capucine,de Talhouët ^[1] ; Noemi,Esteras ^[2] ; Marc P M,Soutar ^[3] ; Benjamin,O'Callaghan ^[1] ; Helene,Plun-Favreau ^[4]

作者单位： Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK. ^[1] Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. ^[2] Department of Biochemistry and Molecular Biology, School of Medicine, Complutense University of Madrid, Madrid, Spain. ^[3] Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK. ben.ocallaghan@ucl.ac.uk. ^[4] Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. ben.ocallaghan@ucl.ac.uk. ^[5] Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK. h.plun-favreau@ucl.ac.uk. ^[6] Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. h.plun-favreau@ucl.ac.uk. ^[7]

关键词 Autophagy KAT8 MG149 Mitophagy Parkinson’s disease

主题词人类(Humans);蛋白激酶类(Protein Kinases);泛素蛋白连接酶类(Ubiquitin-Protein Ligases);线粒体(Mitochondria);组蛋白酰基转移酶(Histone Acetyltransferases);磷酰化(Phosphorylation);膜电位, 线粒体(Membrane Potential, Mitochondrial)

DOI 10.1038/s41598-024-60602-9

PMID 38777823

发布时间 2024-05-30

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准确一般字义偏差语意偏离译文作用小提交