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首页> Journal of medicinal chemistry> Thiosemicarbazone Mixed-Valence Cu(I/II) Complex against Lung Adenocarcinoma Cells through Multiple Pathways Involving Cuproptosis.

Thiosemicarbazone Mixed-Valence Cu(I/II) Complex against Lung Adenocarcinoma Cells through Multiple Pathways Involving Cuproptosis.

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作者： Aili,Li ^[1] ; Kai,Huang ^[2] ; Weiping,Pan ^[3] ; Youru,Wu ^[4] ; Yuwei,Liang ^[1] ; ZhenLei,Zhang ^[1] ; Daqi,Wu ^[4] ; Libing,Ma ^[5] ; Yi,Gou ^[1]

作者单位： Laboratory of Respiratory Diseases, The Affiliated Hospital of Guilin Medical University, Guilin 541001, P. R. China. ^[1] Key Laboratory of Basic Research on Respiratory Diseases, Guangxi Health Commission, Guilin 541001, P. R. China. ^[2] Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, Guilin Medical University, Guilin 541001, P. R. China. ^[3] Department of Scientific Research, The Affiliated Hospital of Guilin Medical University, Guilin 541001, P. R. China. ^[4] School of Chemistry and Pharmaceutical Sciences, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, P. R. China. ^[5]

主题词缩氨硫脲类(Thiosemicarbazones);人类(Humans);铜(Copper);动物(Animals);肺肿瘤(Lung Neoplasms);抗肿瘤药(Antineoplastic Agents);配位络合物(Coordination Complexes);小鼠(Mice);小鼠, 裸(Mice, Nude);细胞系, 肿瘤(Cell Line, Tumor);腺癌(Adenocarcinoma);细胞增殖(Cell Proliferation);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);信号传导(Signal Transduction);构效关系(Structure-Activity Relationship);溶血(Hemolysis);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);小鼠, 近交BALB C(Mice, Inbred BALB C)

DOI 10.1021/acs.jmedchem.4c00257

PMID 38778566

发布时间 2024-06-13

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Journal of medicinal chemistry

Journal of medicinal chemistry

2024年67卷11期

9091-9103页

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