Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus.-论文-万方医学网

第一作者： Colleen,Furey

第一单位： Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

作者： Colleen,Furey ^[1] ; Gabrielle,Scher ^[1] ; Naiqing,Ye ^[1] ; Lisa,Kercher ^[2] ; Jennifer,DeBeauchamp ^[2] ; Jeri Carol,Crumpton ^[2] ; Trushar,Jeevan ^[2] ; Christopher,Patton ^[3] ; John,Franks ^[2] ; Adam,Rubrum ^[2] ; Mohamad-Gabriel,Alameh ^[4] ; Steven H Y,Fan ^[5] ; Anthony T,Phan ^[6] ; Christopher A,Hunter ^[6] ; Richard J,Webby ^[2] ; Drew,Weissman ^[4] ; Scott E,Hensley ^[7]

作者单位： Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[1] Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA. ^[2] Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.;Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA. ^[3] Infectious Disease Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[4] Acuitas Therapeutics, Vancouver, BC, Canada. ^[5] Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[6] Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. hensley@pennmedicine.upenn.edu. ^[7]

医学主题词动物(Animals);流感疫苗(Influenza Vaccines);女(雌)性(Female);小鼠(Mice);雪貂(Ferrets);纳米粒子(Nanoparticles);男(雄)性(Male);流感病毒A型, H5N1亚型(Influenza A Virus, H5N1 Subtype);抗体, 病毒(Antibodies, Viral);血凝素糖蛋白类, 流感病毒(Hemagglutinin Glycoproteins, Influenza Virus);正黏病毒科感染(Orthomyxoviridae Infections);抗体, 中和(Antibodies, Neutralizing);小鼠, 近交BALB C(Mice, Inbred BALB C);禽流感(Influenza in Birds);人类(Humans);RNA, 信使(RNA, Messenger);流感病毒A型, H1N1亚型(Influenza A Virus, H1N1 Subtype);鸟类(Birds);脂类(Lipids);脂质体(Liposomes)

DOI 10.1038/s41467-024-48555-z

PMID 38782954

发布时间 2024-06-03

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Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus.

Nature communications

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Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus.

Nature communications

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Nature communications

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