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Synergistic effects of Smac mimetic APG-1387 with anti-PD-1 antibody are attributed to increased CD3 + NK1.1 + cell recruitment secondary to induction of cytokines from tumor cells.

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作者: Wentao,Pan [1] ; Qiuyun,Luo [2] ; Eric,Liang [3] ; Mude,Shi [2] ; Jian,Sun [1] ; Huimin,Shen [3] ; Zhenhai,Lu [4] ; Lin,Zhang [5] ; Xianglei,Yan [1] ; Luping,Yuan [6] ; Suna,Zhou [1] ; Hanjie,Yi [1] ; Yifan,Zhai [1] ; Miao-Zhen,Qiu [1] ; Dajun,Yang [7]
作者单位: Department of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. [1] Ascentage Pharma (Suzhou) Co, Ltd, Suzhou, Jiangsu Province, China. [2] Department of Clinical Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China. [3] Department of Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. [4] Department of Colorectal Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, China. [5] Department of Clinical Laboratory, Sun Yat-sen University Cancer Center, Guangzhou, China. [6] Ascentage Pharma (Suzhou) Co, Ltd, Suzhou, Jiangsu Province, China. yzhai@ascentage.com. [7] Department of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. qiumzh@sysucc.org.cn. [8] Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China. qiumzh@sysucc.org.cn. [9] Department of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. yangdj@sysucc.org.cn. [10] Ascentage Pharma (Suzhou) Co, Ltd, Suzhou, Jiangsu Province, China. yangdj@sysucc.org.cn. [11]
DOI 10.1186/s12935-024-03373-7
PMID 38790057
发布时间 2024-05-27
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