Unveiling Inter- and Intra-Patient Sequence Variability with a Multi-Sample Coronavirus Target Enrichment Approach.

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作者： Sara,Lado ^[1] ; Jakob,Thannesberger ^[1] ; Kathrin,Spettel ^[2] ; Jurica,Arapović ^[3] ; Bibiana I,Ferreira ^[4] ; Marialuisa,Lavitrano ^[5] ; Christoph,Steininger ^[6]

作者单位： Division of Infectious Diseases and Tropical Medicine, Department of Medicine 1, Medical University of Vienna, 1090 Vienna, Austria. ^[1] Division of Clinical Microbiology, Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.;Division of Biomedical Science, University of Applied Sciences, FH Campus Wien, 1100 Vienna, Austria. ^[2] Department of Medical Biology, School of Medicine, University of Mostar, Bijeli Brijeg b.b., 88000 Mostar, Bosnia and Herzegovina. ^[3] Faculty of Medicine and Biomedical Sciences, University of Algarve, Campus de Gambelas, Edf. 2, 8005-139 Faro, Portugal.;Algarve Biomedical Center Research Institute, Campus de Gambelas, Edf. 2, lab 3.67, 8005-139 Faro, Portugal. ^[4] School of Medicine and Surgery, Milano-Bicocca University, 20900 Monza, Italy. ^[5] Division of Infectious Diseases and Tropical Medicine, Department of Medicine 1, Medical University of Vienna, 1090 Vienna, Austria.;Karl-Landsteiner Institute for Microbiome Research, Medical University of Vienna, 1090 Vienna, Austria. ^[6]

关键词 COVID-19 frequency high throughput metagenomics pandemic target enrichment variants virus

主题词人类(Humans);高通量核苷酸序列分析(High-Throughput Nucleotide Sequencing);突变(Mutation);基因组, 病毒(Genome, Viral);遗传变异(Genetic Variation);进化, 分子(Evolution, Molecular)

DOI 10.3390/v16050786

PMID 38793667

发布时间 2024-11-14

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