Early life interventions metformin and trodusquemine metabolically reprogram the developing mouse liver through transcriptomic alterations.

导出 OA

翻译打印收藏纠错

作者： Sarah A,Ashiqueali ^[1] ; Augusto,Schneider ^[2] ; Xiang,Zhu ^[1] ; Ewelina,Juszczyk ^[3] ; Mishfak A M,Mansoor ^[1] ; Yun,Zhu ^[4] ; Yimin,Fang ^[4] ; Bianka M,Zanini ^[2] ; Driele N,Garcia ^[2] ; Natalie,Hayslip ^[1] ; David,Medina ^[4] ; Samuel,McFadden ^[4] ; Robert,Stockwell ^[4] ; Rong,Yuan ^[4] ; Andrzej,Bartke ^[4] ; Michael,Zasloff ^[5] ; Shadab,Siddiqi ^[1] ; Michal M,Masternak ^[6]

作者单位： Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, USA. ^[1] Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, Brazil. ^[2] Research & Development Center, Celon Pharma S.A., Kazun Nowy, Poland. ^[3] Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, Illinois, USA. ^[4] MedStar Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC, USA. ^[5] Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, USA.;Department of Head and Neck Surgery, Poznan University of Medical Sciences, Poznan, Poland. ^[6]

关键词 development early life interventions juvenile mice lifespan and healthspan liver metabolism metformin microRNAs and mRNAs postnatal window trodusquemine (3‐N‐1(spermine)‐7, 24‐dihydroxy‐5‐cholestane 24‐sulfate)

主题词动物(Animals);小鼠(Mice);肝(Liver);二甲双胍(Metformin);小鼠, 近交C57BL(Mice, Inbred C57BL);男(雄)性(Male)

DOI 10.1111/acel.14227

PMID 38798180

发布时间 2024-10-20

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交