Small GTPases control macropinocytosis of amyloid precursor protein and cleavage to amyloid-β.

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第一作者： Justin,Chiu

第一单位： Department of Physiology and Pharmacology, The Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.;Robarts Research Institute, The Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

作者： Justin,Chiu ^[1] ; Jordan M,Krupa ^[2] ; Claudia,Seah ^[3] ; Stephen H,Pasternak ^[4]

作者单位： Department of Physiology and Pharmacology, The Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.;Robarts Research Institute, The Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. ^[1] Neuroscience Program, The Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.;Robarts Research Institute, The Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. ^[2] Robarts Research Institute, The Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. ^[3] Department of Physiology and Pharmacology, The Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.;Neuroscience Program, The Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.;Robarts Research Institute, The Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.;Department of Clinical Neurological Sciences, The Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. ^[4]

关键词 Alzheimer disease Amyloid precursor protein Lysosomes Macropinocytosis RhoGTPases

DOI 10.1016/j.heliyon.2024.e31077

PMID 38799759

发布时间 2024-05-28

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2024年10卷10期

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Small GTPases control macropinocytosis of amyloid precursor protein and cleavage to amyloid-β.

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Small GTPases control macropinocytosis of amyloid precursor protein and cleavage to amyloid-β.

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