Molecular determinants for brain targeting by peptides: a meta-analysis approach with experimental validation.

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作者： Marco,Cavaco ^[1] ; Patrícia,Fraga ^[2] ; Javier,Valle ^[1] ; Ruben D M,Silva ^[2] ; Lurdes,Gano ^[3] ; João D G,Correia ^[3] ; David,Andreu ^[4] ; Miguel A R B,Castanho ^[3] ; Vera,Neves ^[4]

作者单位： Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisbon, Portugal. ^[1] Proteomics and Protein Chemistry Unit, Department of Medicine and Life Sciences, Pompeu Fabra University, Dr. Aiguader 88, Barcelona Biomedical Research Park, 08003, Barcelona, Spain. ^[2] Centro de Ciências E Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, CTN, Estrada Nacional 10 (Km 139,7), 2695-066, Bobadela LRS, Portugal. ^[3] Departamento de Engenharia E Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa, CTN, Estrada Nacional 10 (Km 139,7), 2695-066, Bobadela LRS, Portugal. ^[4] Proteomics and Protein Chemistry Unit, Department of Medicine and Life Sciences, Pompeu Fabra University, Dr. Aiguader 88, Barcelona Biomedical Research Park, 08003, Barcelona, Spain. david.andreu@upf.edu. ^[5] Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisbon, Portugal. macastanho@medicina.ulisboa.pt. ^[6] Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisbon, Portugal. veraneves@medicina.ulisboa.pt. ^[7]

关键词 Blood–brain barrier (BBB)Blood–brain barrier peptide shuttles (BBBpS)Brain delivery Cell-penetrating peptides (CPPs)Neurological disorders

主题词血脑屏障(Blood-Brain Barrier);细胞穿透性肽类(Cell-Penetrating Peptides);动物(Animals);脑(Brain);人类(Humans);药物释放系统(Drug Delivery Systems)

DOI 10.1186/s12987-024-00545-5

PMID 38802930

发布时间 2024-05-31

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