Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD-mediated pyroptosis in colorectal cancer.

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作者： Xin,Guan ^[1] ; Ruiqi,Liu ^[2] ; Bojun,Wang ^[1] ; Ruxin,Xiong ^[1] ; Luying,Cui ^[1] ; Yuanyu,Liao ^[1] ; Yuli,Ruan ^[1] ; Lin,Fang ^[3] ; Xiaolin,Lu ^[4] ; Xuefan,Yu ^[1] ; Dan,Su ^[1] ; Yue,Ma ^[1] ; Tianjiao,Dang ^[1] ; Zhuo,Chen ^[1] ; Yuanfei,Yao ^[1] ; Chao,Liu ^[1] ; Yanqiao,Zhang ^[1]

作者单位： Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.;Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.;Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China. ^[1] Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China. ^[2] Phase I Clinical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, China. ^[3] Department of Orthopedic Surgery, Harbin Medical University Cancer Hospital, Harbin, China. ^[4]

关键词 H3K27ac HDAC2 NLRP3 colorectal cancer pyroptosis

主题词动物(Animals);人类(Humans);小鼠(Mice);抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);结直肠肿瘤(Colorectal Neoplasms);组蛋白脱乙酰基酶2(Histone Deacetylase 2);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);磷酸结合蛋白质类(Phosphate-Binding Proteins)

DOI 10.1002/ctm2.1692

PMID 38804602

发布时间 2025-01-10

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Clinical and translational medicine

2024年14卷6期

e1692页

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Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD-mediated pyroptosis in colorectal cancer.

Clinical and translational medicine

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Clinical and translational medicine

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Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD-mediated pyroptosis in colorectal cancer.

Clinical and translational medicine

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Clinical and translational medicine

相关期刊

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