首页> Human reproduction update> Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations.

Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations.

导出 OA

翻译打印收藏纠错

第一作者： Antonio,Capalbo

第一单位： Juno Genetics, Department of Reproductive Genetics, Rome, Italy.;Center for Advanced Studies and Technology (CAST), Department of Medical Genetics, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.

作者： Antonio,Capalbo ^[1] ; Guido,de Wert ^[2] ; Heidi,Mertes ^[3] ; Liraz,Klausner ^[4] ; Edith,Coonen ^[5] ; Francesca,Spinella ^[6] ; Hilde,Van de Velde ^[7] ; Stephane,Viville ^[8] ; Karen,Sermon ^[9] ; Nathalie,Vermeulen ^[10] ; Todd,Lencz ^[11] ; Shai,Carmi ^[4]

作者单位： Juno Genetics, Department of Reproductive Genetics, Rome, Italy.;Center for Advanced Studies and Technology (CAST), Department of Medical Genetics, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy. ^[1] Department of Health, Ethics & Society, CAPHRI-School for Public Health and Primary Care and GROW School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands. ^[2] Department of Philosophy and Moral Sciences, Ghent University, Ghent, Belgium.;Department of Public Health and Primary Care, Ghent University, Ghent, Belgium. ^[3] Braun School of Public Health and Community Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. ^[4] Departments of Clinical Genetics and Reproductive Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.;School for Oncology and Developmental Biology, GROW, Maastricht University, Maastricht, The Netherlands. ^[5] Eurofins GENOMA Group Srl, Molecular Genetics Laboratories, Department of Scientific Communication, Rome, Italy. ^[6] Research Group Genetics Reproduction and Development (GRAD), Vrije Universiteit Brussel, Brussel, Belgium.;Brussels IVF, UZ Brussel, Brussel, Belgium. ^[7] Laboratoire de Génétique Médicale LGM, Institut de Génétique Médicale d'Alsace IGMA, INSERM UMR 1112, Université de Strasbourg, France.;Laboratoire de Diagnostic Génétique, Unité de Génétique de l'infertilité (UF3472), Hôpitaux Universitaires de Strasbourg, Strasbourg, France. ^[8] Research Group Genetics Reproduction and Development (GRAD), Vrije Universiteit Brussel, Brussel, Belgium. ^[9] ESHRE Central Office, Strombeek-Bever, Belgium. ^[10] Institute of Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, NY, USA.;Departments of Psychiatry and Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA. ^[11]

关键词 PGT-P clinical considerations disease risk reduction ethical considerations polygenic embryo screening polygenic risk scores preimplantation genetic testing statistical genetics