Biallelic variants in LARS1 induce steatosis in developing zebrafish liver via enhanced autophagy.

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第一作者： Masanori,Inoue

第一单位： Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan.

作者： Masanori,Inoue ^[1] ; Wulan Apridita,Sebastian ^[1] ; Shota,Sonoda ^[1] ; Hiroaki,Miyahara ^[2] ; Nobuyuki,Shimizu ^[3] ; Hiroshi,Shiraishi ^[3] ; Miwako,Maeda ^[1] ; Kumiko,Yanagi ^[4] ; Tadashi,Kaname ^[4] ; Reiko,Hanada ^[5] ; Toshikatsu,Hanada ^[6] ; Kenji,Ihara ^[7]

作者单位： Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan. ^[1] Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Aichi, Japan. ^[2] Department of Cell Biology, Oita University Faculty of Medicine, Oita, Japan. ^[3] Department of Genome Medicine, National Center for Child Health and Development, Tokyo, Japan. ^[4] Department of Neurophysiology, Oita University Faculty of Medicine, Oita, Japan. ^[5] Department of Cell Biology, Oita University Faculty of Medicine, Oita, Japan. thanada@oita-u.ac.jp. ^[6] Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan. k-ihara@oita-u.ac.jp. ^[7]

关键词 Autophagy DGAT1 Fatty liver ILFS1 LARS1

主题词动物(Animals);人类(Humans);自噬(Autophagy);疾病模型, 动物(Disease Models, Animal);脂肪肝(Fatty Liver);肝(Liver);斑马鱼(Zebrafish)

DOI 10.1186/s13023-024-03226-6

PMID 38807157

发布时间 2024-08-22

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