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Disruption of PABPN1 phase separation by SNRPD2 drives colorectal cancer cell proliferation and migration through promoting alternative polyadenylation of CTNNBIP1.

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第一作者： Zhijie,Hu

第一单位： State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Department of Biochemistry, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.

作者： Zhijie,Hu ^[1] ; Mengxia,Li ^[1] ; Yufeng,Chen ^[2] ; Liutao,Chen ^[1] ; Yuting,Han ^[1] ; Chengyong,Chen ^[1] ; Xin,Lu ^[1] ; Nan,You ^[3] ; Yawen,Lou ^[3] ; Yingye,Huang ^[1] ; Zhanfeng,Huo ^[1] ; Chao,Liu ^[1] ; Cheng,Liang ^[1] ; Susu,Liu ^[1] ; Ke,Deng ^[1] ; Liangfu,Chen ^[1] ; Shangwu,Chen ^[1] ; Guohui,Wan ^[3] ; Xiaojian,Wu ^[4] ; Yonggui,Fu ^[5] ; Anlong,Xu ^[6]

作者单位： State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Department of Biochemistry, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China. ^[1] Department of General Surgery (Colorectal Surgery) & Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases & Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China. ^[2] National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation, National Engineering Research Center for New Drug and Druggability (cultivation), Guangdong Province Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. ^[3] Department of General Surgery (Colorectal Surgery) & Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases & Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China. wuxjian@mail.sysu.edu.cn. ^[4] State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Department of Biochemistry, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China. fuyg@mail.sysu.edu.cn. ^[5] State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Department of Biochemistry, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China. lssxal@mail.sysu.edu.cn.;School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China. lssxal@mail.sysu.edu.cn. ^[6]

关键词 CTNNBIP1 PABPN1 SNRPD2 alternative polyadenylation colorectal cancer liquid-liquid phase separation