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TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation.

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作者单位: Department of Physiology, Faculty of Pharmacy, University of Valencia, Burjassot, Valencia, Spain.;Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77, Stockholm, Sweden. [1] Department of Physiology, Faculty of Pharmacy, University of Valencia, Burjassot, Valencia, Spain.;Department of Physiology and Pharmacology, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil. [2] Department of Physiology, Faculty of Pharmacy, University of Valencia, Burjassot, Valencia, Spain. [3] Redox Homeostasis Group, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. [4] Centro de Biología Molecular "Severo Ochoa" (CBMSO), CSIC-UAM, Madrid, Spain. [5] Centro de Biología Molecular "Severo Ochoa" (CBMSO), CSIC-UAM, Madrid, Spain.;Unidad de Técnicas Bioanalíticas (BAT), Instituto de Investigación de Ciencias de la Alimentación (CIAL), CSIC-UAM, Madrid, Spain. [6] Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK. [7] Institute of Medical Chemistry, CSIC, Madrid, Spain. [8] Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77, Stockholm, Sweden. [9] Department of Molecular Immunology and Toxicology and the National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary.;Molecular Medicine Division, Semmelweis University Doctoral College, Budapest, Hungary. [10] Department of Molecular Immunology and Toxicology and the National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary.;Kálmán Laki Doctoral School, University of Debrecen, Debrecen, Hungary. [11] Instituto Cavanilles de Biodiversidad y Biología Evolutiva, Universidad de Valencia, Paterna, Valencia, Spain. [12] Department of Molecular Immunology and Toxicology and the National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary.;Department of Anatomy and Histology, HUN-REN-UVMB Laboratory of Redox Biology, University of Veterinary Medicine, Budapest, Hungary.;Chemistry Institute, University of Debrecen, Debrecen, Hungary. [13] Department of Anatomy and Histology, HUN-REN-UVMB Laboratory of Redox Biology, University of Veterinary Medicine, Budapest, Hungary.;Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, USA. [14] Unidad de Investigación, Hospital Universitario Santa Cristina, Instituto de Investigación Sanitaria Princesa (IIS_IP), Madrid, Spain. [15] Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77, Stockholm, Sweden. elias.arner@ki.se.;Department of Selenoprotein Research and the National Tumor Biology Laboratory, National Insitute of Oncology, Budapest, Hungary. elias.arner@ki.se. [16] Department of Physiology, Faculty of Pharmacy, University of Valencia, Burjassot, Valencia, Spain. juan.sastre@uv.es. [17]
DOI 10.1038/s44318-024-00117-1
PMID 38811853
发布时间 2024-11-13
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