Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes.

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第一作者： Noam,Levin

第一单位： Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA sar@nih.gov peter.kim@nih.gov noam.levin@nih.gov.

作者： Noam,Levin ^[1] ; Sanghyun P,Kim ^[1] ; Charles A,Marquardt ^[2] ; Nolan R,Vale ^[2] ; Zhiya,Yu ^[2] ; Sivasish,Sindiri ^[2] ; Jared J,Gartner ^[2] ; Maria,Parkhurst ^[2] ; Sri,Krishna ^[2] ; Frank J,Lowery ^[2] ; Nikolaos,Zacharakis ^[2] ; Lior,Levy ^[2] ; Todd D,Prickett ^[2] ; Tiffany,Benzine ^[2] ; Satyajit,Ray ^[2] ; Robert V,Masi ^[2] ; Billel,Gasmi ^[2] ; Yong,Li ^[2] ; Rafiqul,Islam ^[2] ; Alakesh,Bera ^[2] ; Stephanie L,Goff ^[2] ; Paul F,Robbins ^[2] ; Steven A,Rosenberg ^[1]

作者单位： Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA sar@nih.gov peter.kim@nih.gov noam.levin@nih.gov. ^[1] Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. ^[2]

关键词 Adoptive cell therapy - ACT T cell Receptor - TCR Tumor infiltrating lymphocyte - TIL

主题词人类(Humans);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);抗原, 肿瘤(Antigens, Neoplasm);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);小鼠(Mice);免疫记忆(Immunologic Memory);动物(Animals);女(雌)性(Female);表型(Phenotype);肿瘤(Neoplasms)

DOI 10.1136/jitc-2023-008645

PMID 38816232

发布时间 2024-06-03

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Journal for immunotherapy of cancer

2024年12卷5期

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Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

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Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

相关期刊

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