A quick and innovative pipeline for producing chondrocyte-homing peptide-modified extracellular vesicles by three-dimensional dynamic culture of hADSCs spheroids to modulate the fate of remaining ear chondrocytes in the M1 macrophage-infiltrated microenvironment.

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第一作者： Jianguo,Chen

第一单位： Chinese Academy of Medical Sciences & Peking Union Medical College Plastic Surgery Hospital and Institute, Shijingshan District, Beijing, 100144, China.

作者： Jianguo,Chen ^[1] ; Enchong,Zhang ^[2] ; Yingying,Wan ^[3] ; Tianyu,Huang ^[1] ; Yuchen,Wang ^[1] ; Haiyue,Jiang ^[4]

作者单位： Chinese Academy of Medical Sciences & Peking Union Medical College Plastic Surgery Hospital and Institute, Shijingshan District, Beijing, 100144, China. ^[1] Department of Urology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, 110004, China. nczhang@cmu.edu.cn. ^[2] DongFang Hospital of Beijing University of Chinese Medicine, Fengtai District, Beijing, 100078, China. 17801222640@163.com. ^[3] Chinese Academy of Medical Sciences & Peking Union Medical College Plastic Surgery Hospital and Institute, Shijingshan District, Beijing, 100144, China. jianghypsh@163.com. ^[4]

关键词 Adipose-derived mesenchymal stem cells Chondrocyte homing peptide Extracellular vesicles M1 macrophage Remaining ear chondrocytes