Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification.
作者:
Paul S,de Vries [1]
;
Matthew P,Conomos [2]
;
Kuldeep,Singh [3]
;
Christopher J,Nicholson [3]
;
Deepti,Jain [2]
;
Natalie R,Hasbani [1]
;
Wanlin,Jiang [3]
;
Sujin,Lee [3]
;
Christian L,Lino Cardenas [3]
;
Sharon M,Lutz [4]
;
Doris,Wong [5]
;
Xiuqing,Guo [6]
;
Jie,Yao [7]
;
Erica P,Young [7]
;
Catherine,Tcheandjieu [8]
;
Austin T,Hilliard [9]
;
Joshua C,Bis [10]
;
Lawrence F,Bielak [9]
;
Michael R,Brown [11]
;
Shaila,Musharoff [12]
;
Shoa L,Clarke [13]
;
James G,Terry [1]
;
Nicholette D,Palmer [9]
;
Lisa R,Yanek [14]
;
Huichun,Xu [9]
;
Nancy,Heard-Costa [10]
;
Jennifer,Wessel [15]
;
Margaret Sunitha,Selvaraj [16]
;
Rebecca H,Li [17]
;
Xiao,Sun [18]
;
Adam W,Turner [19]
;
Adrienne M,Stilp [20]
;
Alyna,Khan [21]
;
Anne B,Newman [22]
;
Asif,Rasheed [23]
;
Barry I,Freedman [24]
;
Brian G,Kral [25]
;
Caitlin P,McHugh [3]
;
Chani,Hodonsky [26]
;
Danish,Saleheen [27]
;
David M,Herrington [6]
;
David R,Jacobs [2]
;
Deborah A,Nickerson [2]
;
Eric,Boerwinkle [28]
;
Fei Fei,Wang [29]
;
Gerardo,Heiss [30]
;
Goo,Jun [31]
;
Greg L,Kinney [2]
;
Haakon H,Sigurslid [6]
;
HarshaVardhan,Doddapaneni [29]
;
Ira M,Hall [32]
;
Isabela M,Bensenor [33]
;
Jai,Broome [34]
;
James D,Crapo [35]
;
James G,Wilson [36]
;
Jennifer A,Smith [37]
;
John,Blangero [1]
;
Jose D,Vargas [38]
;
Jose Verdezoto,Mosquera [2]
;
Joshua D,Smith [39]
;
Karine A,Viaud-Martinez [1]
;
Kathleen A,Ryan [40]
;
Kendra A,Young [3]
;
Kent D,Taylor [38]
;
Leslie A,Lange [41]
;
Leslie S,Emery [42]
;
Marcio S,Bittencourt [2]
;
Matthew J,Budoff [43]
;
May E,Montasser [44]
;
Miao,Yu [13]
;
Michael C,Mahaney [45]
;
Mohammed S,Mahamdeh [46]
;
Myriam,Fornage [47]
;
Nora,Franceschini [48]
;
Paulo A,Lotufo [6]
;
Pradeep,Natarajan [36]
;
Quenna,Wong [37]
;
Rasika A,Mathias [49]
;
Richard A,Gibbs [18]
;
Ron,Do [40]
;
Roxana,Mehran [7]
;
Russell P,Tracy [50]
;
Ryan W,Kim [2]
;
Sarah C,Nelson [42]
;
Scott M,Damrauer [51]
;
Sharon L R,Kardia [18]
;
Stephen S,Rich [13]
;
Valentin,Fuster [46]
;
Valerio,Napolioni [47]
;
Wei,Zhao [3]
;
Wenjie,Tian [1]
;
Xianyong,Yin [52]
;
Yuan-I,Min [53]
;
Alisa K,Manning [42]
;
Gina,Peloso [23]
;
Tanika N,Kelly [24]
;
Christopher J,O'Donnell [25]
;
Alanna C,Morrison [2]
;
Joanne E,Curran [17]
;
Warren M,Zapol [54]
;
Donald W,Bowden [38]
;
Lewis C,Becker [55]
;
Adolfo,Correa [56]
;
Braxton D,Mitchell [57]
;
Bruce M,Psaty [58]
;
John Jeffrey,Carr [59]
;
Alexandre C,Pereira [60]
;
Themistocles L,Assimes [2]
;
Nathan O,Stitziel [61]
;
John E,Hokanson [62]
;
Cecelia A,Laurie [13]
;
Jerome I,Rotter [6]
;
Ramachandran S,Vasan [63]
;
Wendy S,Post [64]
;
Patricia A,Peyser [65]
;
Clint L,Miller [13]
;
Rajeev,Malhotra [3]
作者单位:
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
[1]
Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
[2]
Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
[3]
PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
[4]
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
[5]
Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.
[6]
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
[7]
Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
[8]
VA Palo Alto Healthcare System, Palo Alto, CA, USA.
[9]
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
[10]
Palo Alto Veterans Institute for Research, Palo Alto, CA, USA.
[11]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
[12]
School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
[13]
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
[14]
Department of Radiology, Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, TN, USA.
[15]
Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
[16]
Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
[17]
Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
[18]
Boston University School of Medicine, Boston, MA, USA.
[19]
Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.
[20]
Department of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.
[21]
Diabetes Translational Research Center, Indiana University, Indianapolis, IN, USA.
[22]
Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
[23]
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
[24]
Department of Medicine, Harvard Medical School, Boston, MA, USA.
[25]
School of Public Health and Tropical Medicine, Department of Epidemiology, Tulane University, New Orleans, LA, USA.
[26]
College of Medicine, Department of Medicine, Division of Nephrology, University of Illinois Chicago, Chicago, IL, USA.
[27]
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
[28]
Center For Non-Communicable Diseases, Karachi, Pakistan.
[29]
Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
[30]
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
[31]
Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
[32]
Department of Cardiology, Columbia University Irving Medical Center, New York, NY, USA.
[33]
Department of Internal Medicine, Section of Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
[34]
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
[35]
Department of Genome Sciences, University of Washington, Seattle, WA, USA.
[36]
Northwest Genomics Center, University of Washington, Seattle, WA, USA.
[37]
Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
[38]
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
[39]
Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
[40]
Yale Center for Genomic Health, Yale School of Medicine, New Haven, CT, USA.
[41]
Center for Clinical and Epidemiological Research, University Hospital, University of Sao Paulo Medical School, São Paulo, Brazil.
[42]
Department of Medicine, National Jewish Health, Denver, CO, USA.
[43]
Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
[44]
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
[45]
Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
[46]
South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
[47]
Medstar Heart and Vascular Institute, Medstar Georgetown University Hospital, Washington, DC, USA.
[48]
Illumina Laboratory Services, Illumina Inc., San Diego, CA, USA.
[49]
Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
[50]
Department of Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
[51]
Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
[52]
Department of Epidemiology, Gillings School of Global Public health, University of North Carolina, Chapel Hill, NC, USA.
[53]
Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
[54]
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
[55]
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[56]
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[57]
Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[58]
Department of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT, USA.
[59]
Psomagen Inc., Rockville, MD, USA.
[60]
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
[61]
Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
[62]
Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
[63]
Mount Sinai Heart Center, New York, NY, USA.
[64]
Genomic And Molecular Epidemiology (GAME) Lab, School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
[65]
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
[66]
Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
[67]
Clinical and Translation Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
[68]
Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
[69]
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[70]
VA Boston Healthcare System, Boston, MA, USA.
[71]
Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
[72]
Department of Anesthesia, Critical Care and Pain Medicine at Massachusetts General Hospital, Boston, MA, USA.
[73]
Department of Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA.
[74]
Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.
[75]
Department of Epidemiology, University of Washington, Seattle, WA, USA.
[76]
Department of Health Services, University of Washington, Seattle, WA, USA.
[77]
Department of Genetics, Harvard Medical School, Boston, MA, USA.
[78]
Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, Brazil.
[79]
Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
[80]
McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
[81]
Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
[82]
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
[83]
DOI
10.1038/s44161-023-00375-y
PMID
38817323
发布时间
2024-06-25
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Nature cardiovascular research
Nature cardiovascular research
2023年2卷12期
1159-1172页
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