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Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification.

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作者: Paul S,de Vries [1] ; Matthew P,Conomos [2] ; Kuldeep,Singh [3] ; Christopher J,Nicholson [3] ; Deepti,Jain [2] ; Natalie R,Hasbani [1] ; Wanlin,Jiang [3] ; Sujin,Lee [3] ; Christian L,Lino Cardenas [3] ; Sharon M,Lutz [4] ; Doris,Wong [5] ; Xiuqing,Guo [6] ; Jie,Yao [7] ; Erica P,Young [7] ; Catherine,Tcheandjieu [8] ; Austin T,Hilliard [9] ; Joshua C,Bis [10] ; Lawrence F,Bielak [9] ; Michael R,Brown [11] ; Shaila,Musharoff [12] ; Shoa L,Clarke [13] ; James G,Terry [1] ; Nicholette D,Palmer [9] ; Lisa R,Yanek [14] ; Huichun,Xu [9] ; Nancy,Heard-Costa [10] ; Jennifer,Wessel [15] ; Margaret Sunitha,Selvaraj [16] ; Rebecca H,Li [17] ; Xiao,Sun [18] ; Adam W,Turner [19] ; Adrienne M,Stilp [20] ; Alyna,Khan [21] ; Anne B,Newman [22] ; Asif,Rasheed [23] ; Barry I,Freedman [24] ; Brian G,Kral [25] ; Caitlin P,McHugh [3] ; Chani,Hodonsky [26] ; Danish,Saleheen [27] ; David M,Herrington [6] ; David R,Jacobs [2] ; Deborah A,Nickerson [2] ; Eric,Boerwinkle [28] ; Fei Fei,Wang [29] ; Gerardo,Heiss [30] ; Goo,Jun [31] ; Greg L,Kinney [2] ; Haakon H,Sigurslid [6] ; HarshaVardhan,Doddapaneni [29] ; Ira M,Hall [32] ; Isabela M,Bensenor [33] ; Jai,Broome [34] ; James D,Crapo [35] ; James G,Wilson [36] ; Jennifer A,Smith [37] ; John,Blangero [1] ; Jose D,Vargas [38] ; Jose Verdezoto,Mosquera [2] ; Joshua D,Smith [39] ; Karine A,Viaud-Martinez [1] ; Kathleen A,Ryan [40] ; Kendra A,Young [3] ; Kent D,Taylor [38] ; Leslie A,Lange [41] ; Leslie S,Emery [42] ; Marcio S,Bittencourt [2] ; Matthew J,Budoff [43] ; May E,Montasser [44] ; Miao,Yu [13] ; Michael C,Mahaney [45] ; Mohammed S,Mahamdeh [46] ; Myriam,Fornage [47] ; Nora,Franceschini [48] ; Paulo A,Lotufo [6] ; Pradeep,Natarajan [36] ; Quenna,Wong [37] ; Rasika A,Mathias [49] ; Richard A,Gibbs [18] ; Ron,Do [40] ; Roxana,Mehran [7] ; Russell P,Tracy [50] ; Ryan W,Kim [2] ; Sarah C,Nelson [42] ; Scott M,Damrauer [51] ; Sharon L R,Kardia [18] ; Stephen S,Rich [13] ; Valentin,Fuster [46] ; Valerio,Napolioni [47] ; Wei,Zhao [3] ; Wenjie,Tian [1] ; Xianyong,Yin [52] ; Yuan-I,Min [53] ; Alisa K,Manning [42] ; Gina,Peloso [23] ; Tanika N,Kelly [24] ; Christopher J,O'Donnell [25] ; Alanna C,Morrison [2] ; Joanne E,Curran [17] ; Warren M,Zapol [54] ; Donald W,Bowden [38] ; Lewis C,Becker [55] ; Adolfo,Correa [56] ; Braxton D,Mitchell [57] ; Bruce M,Psaty [58] ; John Jeffrey,Carr [59] ; Alexandre C,Pereira [60] ; Themistocles L,Assimes [2] ; Nathan O,Stitziel [61] ; John E,Hokanson [62] ; Cecelia A,Laurie [13] ; Jerome I,Rotter [6] ; Ramachandran S,Vasan [63] ; Wendy S,Post [64] ; Patricia A,Peyser [65] ; Clint L,Miller [13] ; Rajeev,Malhotra [3]
作者单位: Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. [1] Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA. [2] Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. [3] PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA. [4] Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. [5] Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA. [6] The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. [7] Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA. [8] VA Palo Alto Healthcare System, Palo Alto, CA, USA. [9] Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. [10] Palo Alto Veterans Institute for Research, Palo Alto, CA, USA. [11] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. [12] School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA. [13] Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. [14] Department of Radiology, Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, TN, USA. [15] Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA. [16] Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [17] Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. [18] Boston University School of Medicine, Boston, MA, USA. [19] Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA. [20] Department of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA. [21] Diabetes Translational Research Center, Indiana University, Indianapolis, IN, USA. [22] Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. [23] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. [24] Department of Medicine, Harvard Medical School, Boston, MA, USA. [25] School of Public Health and Tropical Medicine, Department of Epidemiology, Tulane University, New Orleans, LA, USA. [26] College of Medicine, Department of Medicine, Division of Nephrology, University of Illinois Chicago, Chicago, IL, USA. [27] Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. [28] Center For Non-Communicable Diseases, Karachi, Pakistan. [29] Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. [30] Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [31] Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. [32] Department of Cardiology, Columbia University Irving Medical Center, New York, NY, USA. [33] Department of Internal Medicine, Section of Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. [34] Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA. [35] Department of Genome Sciences, University of Washington, Seattle, WA, USA. [36] Northwest Genomics Center, University of Washington, Seattle, WA, USA. [37] Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA. [38] Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA. [39] Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. [40] Yale Center for Genomic Health, Yale School of Medicine, New Haven, CT, USA. [41] Center for Clinical and Epidemiological Research, University Hospital, University of Sao Paulo Medical School, São Paulo, Brazil. [42] Department of Medicine, National Jewish Health, Denver, CO, USA. [43] Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA. [44] Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. [45] Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA. [46] South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA. [47] Medstar Heart and Vascular Institute, Medstar Georgetown University Hospital, Washington, DC, USA. [48] Illumina Laboratory Services, Illumina Inc., San Diego, CA, USA. [49] Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA. [50] Department of Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. [51] Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA. [52] Department of Epidemiology, Gillings School of Global Public health, University of North Carolina, Chapel Hill, NC, USA. [53] Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [54] Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. [55] The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [56] Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [57] Icahn School of Medicine at Mount Sinai, New York, NY, USA. [58] Department of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT, USA. [59] Psomagen Inc., Rockville, MD, USA. [60] Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. [61] Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [62] Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain. [63] Mount Sinai Heart Center, New York, NY, USA. [64] Genomic And Molecular Epidemiology (GAME) Lab, School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy. [65] Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. [66] Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA. [67] Clinical and Translation Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. [68] Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA. [69] Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. [70] VA Boston Healthcare System, Boston, MA, USA. [71] Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. [72] Department of Anesthesia, Critical Care and Pain Medicine at Massachusetts General Hospital, Boston, MA, USA. [73] Department of Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA. [74] Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA. [75] Department of Epidemiology, University of Washington, Seattle, WA, USA. [76] Department of Health Services, University of Washington, Seattle, WA, USA. [77] Department of Genetics, Harvard Medical School, Boston, MA, USA. [78] Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, Brazil. [79] Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. [80] McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA. [81] Department of Medicine, Boston University School of Medicine, Boston, MA, USA. [82] Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. [83]
DOI 10.1038/s44161-023-00375-y
PMID 38817323
发布时间 2024-06-25
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Nature cardiovascular research

Nature cardiovascular research

2023年2卷12期

1159-1172页

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