首页> Cancer discovery> CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells.

CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells.

导出 OA

翻译打印收藏纠错

第一作者： Michael R,Waarts

第一单位： Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.;Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.

作者： Michael R,Waarts ^[1] ; Shoron,Mowla ^[2] ; Meaghan,Boileau ^[3] ; Anthony R,Martinez Benitez ^[2] ; Junya,Sango ^[4] ; Maya,Bagish ^[2] ; Inés,Fernández-Maestre ^[1] ; Yufan,Shan ^[3] ; Shira E,Eisman ^[2] ; Young C,Park ^[2] ; Matthew,Wereski ^[2] ; Isabelle,Csete ^[2] ; Kavi,O'Connor ^[2] ; Angelica C,Romero-Vega ^[2] ; Linde A,Miles ^[5] ; Wenbin,Xiao ^[6] ; Xiaodi,Wu ^[2] ; Richard P,Koche ^[7] ; Scott A,Armstrong ^[3] ; Alan H,Shih ^[8] ; Eirini P,Papapetrou ^[4] ; Jason M,Butler ^[9] ; Sheng F,Cai ^[10] ; Robert L,Bowman ^[11] ; Ross L,Levine ^[2]

作者单位： Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.;Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York. ^[1] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. ^[2] Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. ^[3] Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.;Center for Advancement of Blood Cancer Therapies, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York. ^[4] Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.;Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio. ^[5] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.;Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. ^[6] Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York. ^[7] Division of Hematology Oncology, Department of Medicine, Tisch Cancer Institute (TCI), Icahn School of Medicine at Mount Sinai, New York, New York. ^[8] Department of Medicine, University of Florida Health Cancer Center, Gainesville, Florida. ^[9] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.;Leukemia Service, Department of Medicine, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York. ^[10] Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. ^[11]