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Multi-modal domain adaptation for revealing spatial functional landscape from spatially resolved transcriptomics.

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第一作者： Lequn,Wang

第一单位： Key Laboratory of Systems Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, No. 320 Yue Yang Road, Xuhui District, Shanghai 200031, China.;University of Chinese Academy of Sciences, No. 80 Zhongguancun East Road, Haidian District, Beijing 100049, China.

作者： Lequn,Wang ^[1] ; Yaofeng,Hu ^[2] ; Kai,Xiao ^[1] ; Chuanchao,Zhang ^[2] ; Qianqian,Shi ^[3] ; Luonan,Chen ^[4]

作者单位： Key Laboratory of Systems Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, No. 320 Yue Yang Road, Xuhui District, Shanghai 200031, China.;University of Chinese Academy of Sciences, No. 80 Zhongguancun East Road, Haidian District, Beijing 100049, China. ^[1] Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Xiangshan Lane, Hangzhou 310024, China. ^[2] Hubei Engineering Technology Research Center of Agricultural Big Data, Huazhong Agricultural University, No. 1 Shizishan Street, Hongshan District, Wuhan 430070, Hubei Province, China.;Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, No. 1 Shizishan Street, Hongshan District, Wuhan 430070, Hubei Province, China. ^[3] Key Laboratory of Systems Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, No. 320 Yue Yang Road, Xuhui District, Shanghai 200031, China.;University of Chinese Academy of Sciences, No. 80 Zhongguancun East Road, Haidian District, Beijing 100049, China.;Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Xiangshan Lane, Hangzhou 310024, China. ^[4]

关键词 spatial distribution alignment spatial domain identification spatially resolved transcriptomics unsupervised domain adaptation

主题词人类(Humans);基因表达谱(Gene Expression Profiling);聚类分析(Cluster Analysis);计算生物学(Computational Biology);肿瘤(Neoplasms);算法(Algorithms)

DOI 10.1093/bib/bbae257

PMID 38819253

发布时间 2024-06-03

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