换一批
换一批Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans.
作者：
Samuel D,Chauvin [1]
;
Shoichiro,Ando [2]
;
Joe A,Holley [1]
;
Atsushi,Sugie [3]
;
Fang R,Zhao [4]
;
Subhajit,Poddar [1]
;
Rei,Kato [2]
;
Cathrine A,Miner [1]
;
Yohei,Nitta [3]
;
Siddharth R,Krishnamurthy [5]
;
Rie,Saito [6]
;
Yue,Ning [1]
;
Yuya,Hatano [2]
;
Sho,Kitahara [2]
;
Shin,Koide [2]
;
W Alexander,Stinson [4]
;
Jiayuan,Fu [1]
;
Nehalee,Surve [1]
;
Lindsay,Kumble [1]
;
Wei,Qian [4]
;
Oleksiy,Polishchuk [1]
;
Prabhakar S,Andhey [7]
;
Cindy,Chiang [8]
;
Guanqun,Liu [8]
;
Ludovic,Colombeau [9]
;
Raphaël,Rodriguez [9]
;
Nicolas,Manel [10]
;
Akiyoshi,Kakita [6]
;
Maxim N,Artyomov [7]
;
David C,Schultz [11]
;
P Toby,Coates [12]
;
Elisha D O,Roberson [4]
;
Yasmine,Belkaid [13]
;
Roger A,Greenberg [14]
;
Sara,Cherry [15]
;
Michaela U,Gack [8]
;
Tristan,Hardy [16]
;
Osamu,Onodera [17]
;
Taisuke,Kato [18]
;
Jonathan J,Miner [19]
作者单位：
Division of Rheumatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.;RVCL Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[1]
Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute, Niigata University, Niigata, Japan.
[2]
Department of Neuroscience of Disease, Brain Research Institute, Niigata University, Niigata, Japan.
[3]
Department of Medicine, Washington University in Saint Louis, Saint Louis, MO, USA.
[4]
Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.;NIAID Microbiome Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
[5]
Department of Pathology, Clinical Neuroscience Branch, Brain Research Institute, Niigata University, Niigata, Japan.
[6]
Department of Pathology and Immunology, Washington University in Saint Louis, Saint Louis, MO, USA.
[7]
Department of Microbiology, The University of Chicago, Chicago, IL, USA.;Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, USA.
[8]
Equipe Labellisée Ligue Contre le Cancer, Institut Curie, CNRS, INSERM, PSL Research University, Paris, France.
[9]
INSERM U932, Institut Curie, PSL Research University, Paris, France.
[10]
High-throughput Screening Core, University of Pennsylvania, Philadelphia, PA, USA.
[11]
Central and Northern Adelaide Renal and Transplantation Service (CNARTS), The Royal Adelaide Hospital, Adelaide, South Australia, Australia.;School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia.
[12]
Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.;NIAID Microbiome Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.;Institut Pasteur, Paris, France.
[13]
Department of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
[14]
Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.;Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[15]
Genetics, Repromed, Monash IVF, Dulwich, South Australia, Australia.;Genetics and Molecular Pathology, SA Pathology, Adelaide, Australia.
[16]
Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute, Niigata University, Niigata, Japan.;Department of Molecular Neuroscience, Brain Science Branch, Brain Research Institute, Niigata University, Niigata, Japan.
[17]
Department of Molecular Neuroscience, Brain Science Branch, Brain Research Institute, Niigata University, Niigata, Japan. taisuke8077@bri.niigata-u.ac.jp.
[18]
Division of Rheumatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Jonathan.Miner@PennMedicine.UPenn.edu.;RVCL Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Jonathan.Miner@PennMedicine.UPenn.edu.;Department of Medicine, Washington University in Saint Louis, Saint Louis, MO, USA. Jonathan.Miner@PennMedicine.UPenn.edu.;Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Jonathan.Miner@PennMedicine.UPenn.edu.;Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Jonathan.Miner@PennMedicine.UPenn.edu.;Penn Colton Center for Autoimmunity, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Jonathan.Miner@PennMedicine.UPenn.edu.
[19]
主题词
动物(Animals);脱氧核糖核酸外切酶类(Exodeoxyribonucleases);人类(Humans);磷蛋白类(Phosphoproteins);小鼠(Mice);DNA损伤(DNA Damage);表型(Phenotype);突变(Mutation);果蝇属(Drosophila);衰老(Aging);女(雌)性(Female);黑腹果蝇(Drosophila melanogaster);男(雄)性(Male);视网膜疾病(Retinal Diseases);血管疾病(Vascular Diseases);遗传性中枢神经系统脱髓鞘疾病(Hereditary Central Nervous System Demyelinating Diseases)
DOI
10.1038/s41467-024-49066-7
PMID
38824133
发布时间
2025-01-15
- 浏览2
Nature communications
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