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TORSEL, a 4EBP1-based mTORC1 live-cell sensor, reveals nutrient-sensing targeting by histone deacetylase inhibitors.

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第一作者： Canrong,Li

第一单位： School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, China.

作者： Canrong,Li ^[1] ; Yuguo,Yi ^[1] ; Yingyi,Ouyang ^[1] ; Fengzhi,Chen ^[1] ; Chuxin,Lu ^[1] ; Shujun,Peng ^[1] ; Yifan,Wang ^[1] ; Xinyu,Chen ^[1] ; Xiao,Yan ^[1] ; Haolun,Xu ^[1] ; Shuiming,Li ^[2] ; Lin,Feng ^[3] ; Xiaoduo,Xie ^[4]

作者单位： School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, China. ^[1] College of Life Sciences and Oceanography, Shenzhen Key Laboratory of Microbial Genetic Engineering, Shenzhen University, Shenzhen, China. ^[2] Department of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. ^[3] School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, China. xiexd8@mail.sysu.edu.cn.;Department of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. xiexd8@mail.sysu.edu.cn. ^[4]

关键词 Amino acid sensing HDAC inhibitor Live-cell sensor Panobinostat mTORC1

DOI 10.1186/s13578-024-01250-4

PMID 38824577

发布时间 2024-06-04

基金项目

31871439/National Natural Science Foundation of China JCYJ20190807161213744/Shenzhen Science and Technology Innovation Program JCYJ20220530145613030/Shenzhen Science and Technology Innovation Program 2019A1515011105/Natural Science Foundation of Guangdong Province 2023A1515011923/Natural Science Foundation of Guangdong Province

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