Asymmetric allostery in estrogen receptor-α homodimers drives responses to the ensemble of estrogens in the hormonal milieu.

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作者： Charles K,Min ^[1] ; Jerome C,Nwachukwu ^[2] ; Yingwei,Hou ^[3] ; Robin J,Russo ^[1] ; Alexandra,Papa ^[4] ; Jian,Min ^[5] ; Rouming,Peng ^[5] ; Sung Hoon,Kim ^[3] ; Yvonne,Ziegler ^[6] ; Erumbi S,Rangarajan ^[2] ; Tina,Izard ^[1] ; Benita S,Katzenellenbogen ^[6] ; John A,Katzenellenbogen ^[3] ; Kendall W,Nettles ^[2]

作者单位： Department of Immunology and Microbiology, The Herbert Wertheim University of Florida Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL 33458.;The Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, CA 92037. ^[1] Department of Immunology and Microbiology, The Herbert Wertheim University of Florida Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL 33458. ^[2] Department of Chemistry and Cancer Center, University of Illinois at Urbana-Champaign, Urbana, IL 61801. ^[3] Department of Immunology and Microbiology, The Herbert Wertheim University of Florida Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL 33458.;Florida Atlantic University, Jupiter, FL 33458. ^[4] State Key Laboratory of Biocatalysis and Enzyme Engineering, National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, School of Life Sciences, Hubei University, Wuhan 430062, China. ^[5] Department of Molecular and Integrative Physiology, Cancer Center at University of Illinois at Urbana-Champaign, Urbana, IL 61801. ^[6]

关键词 X-ray crystallography estrogen receptor molecular dynamics simulations