首页> Journal of proteome research> Increasing Proteome Coverage Through a Reduction in Analyte Complexity in Single-Cell Equivalent Samples.

Increasing Proteome Coverage Through a Reduction in Analyte Complexity in Single-Cell Equivalent Samples.

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第一作者： Marion,Pang

第一单位： Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, United States.

作者： Marion,Pang ^[1] ; Jeff J,Jones ^[2] ; Ting-Yu,Wang ^[2] ; Baiyi,Quan ^[3] ; Nicole J,Kubat ^[3] ; Yanping,Qiu ^[2] ; Michael L,Roukes ^[4] ; Tsui-Fen,Chou ^[2]

作者单位： Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, United States. ^[1] Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, United States.;Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, United States. ^[2] Division of Physics, Mathematics and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, United States. ^[3] Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, United States.;Division of Physics, Mathematics and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, United States.;Division of Engineering and Applied Science, California Institute of Technology, 1200 East California Blvd, Pasadena, California 91125, United States. ^[4]

关键词 bottom-up proteomics peptide identification optimization protease choice single-cell proteomics

医学主题词单细胞分析(Single-Cell Analysis);蛋白质组(Proteome);蛋白质组学(Proteomics);人类(Humans);胰蛋白酶(Trypsin);色谱法, 液相(Chromatography, Liquid);质谱分析法(Mass Spectrometry)

DOI 10.1021/acs.jproteome.4c00062

PMID 38832920

发布时间 2025-07-21

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