Sunitinib for the treatment of metastatic gastrointestinal stromal tumors: the effect of TDM-guided dose optimization on clinical outcomes.

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第一作者： E L,Giraud

第一单位： Department of Pharmacy, Radboud University Medical Center, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: https://twitter.com/ElineGirau45556.

作者： E L,Giraud ^[1] ; K,Westerdijk ^[2] ; M B A,van der Kleij ^[3] ; N A D,Guchelaar ^[4] ; M,Meertens ^[5] ; R F,Bleckman ^[6] ; A,Rieborn ^[7] ; M,Mohammadi ^[8] ; E,Roets ^[9] ; R H J,Mathijssen ^[4] ; A D R,Huitema ^[10] ; S L W,Koolen ^[11] ; H,Gelderblom ^[8] ; D J A R,Moes ^[7] ; A K L,Reyners ^[6] ; D J,Touw ^[12] ; P,Keizer-Heldens ^[13] ; A W,Oosten ^[4] ; W T A,van der Graaf ^[9] ; N,Steeghs ^[9] ; N P,van Erp ^[14] ; I M E,Desar ^[15] ; Dutch Pharmacology Oncology Group (DPOG)

作者单位： Department of Pharmacy, Radboud University Medical Center, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: https://twitter.com/ElineGirau45556. ^[1] Department of Medical Oncology, Radboud University Medical Center, Radboud University Medical Center, Nijmegen, The Netherlands. ^[2] Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. ^[3] Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. ^[4] Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. ^[5] Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. ^[6] Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands. ^[7] Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands. ^[8] Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. ^[9] Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Department of Pharmacology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. ^[10] Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands; Department of Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands. ^[11] Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. ^[12] Department of Medical Oncology, Rijnstate Hospital, Arnhem, The Netherlands. ^[13] Department of Pharmacy, Radboud University Medical Center, Radboud University Medical Center, Nijmegen, The Netherlands. ^[14] Department of Medical Oncology, Radboud University Medical Center, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Ingrid.desar@radboudumc.nl. ^[15]

关键词 gastrointestinal stromal tumor personalized dosing pharmacokinetic-guided dosing sunitinib therapeutic drug monitoring

主题词人类(Humans);胃肠道间质肿瘤(Gastrointestinal Stromal Tumors);女(雌)性(Female);男(雄)性(Male);中年人(Middle Aged);老年人(Aged);抗肿瘤药(Antineoplastic Agents);回顾性研究(Retrospective Studies);药物监测(Drug Monitoring);成年人(Adult);治疗结果(Treatment Outcome);胃肠肿瘤(Gastrointestinal Neoplasms);剂量效应关系, 药物(Dose-Response Relationship, Drug);老年人, 80以上(Aged, 80 and over);前瞻性研究(Prospective Studies)

DOI 10.1016/j.esmoop.2024.103477

PMID 38833964

发布时间 2024-06-24

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2024年9卷6期

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Sunitinib for the treatment of metastatic gastrointestinal stromal tumors: the effect of TDM-guided dose optimization on clinical outcomes.

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Sunitinib for the treatment of metastatic gastrointestinal stromal tumors: the effect of TDM-guided dose optimization on clinical outcomes.

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