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In silico predicted compound targeting the IQGAP1-GRD domain selectively inhibits growth of human acute myeloid leukemia.

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作者单位: Wilmot Cancer Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Box 704, Rochester, NY, 14618, USA. Deepak_Sahasrabudhe@urmc.rochester.edu. [1] Department of Medicine, Hematology/Oncology, University of Rochester Medical Center, Rochester, NY, USA. Deepak_Sahasrabudhe@urmc.rochester.edu. [2] Wilmot Cancer Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Box 704, Rochester, NY, 14618, USA. [3] Department of Medicine, Hematology/Oncology, University of Rochester Medical Center, Rochester, NY, USA. [4] Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, US. [5] Department of Chemistry, Birla Institute of Technology, Ranchi, Jharkhand, India. [6] Genomics Research Center, University of Rochester Medical Center, Rochester, NY, USA. [7] Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA. [8] Department of Psychological and Brain Sciences, Colgate University, Hamilton, NY, USA. [9] Indiana University School of Medicine, Indianapolis, IN, USA. [10] Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, 14642, USA. [11] Division of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY, USA. [12] Presude Lifesciences Pvt Ltd., Uttam Nagar, New Delhi, 110059, India. [13] Division of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY, USA. Rakesh_Singh@urmc.rochester.edu. [14] Wilmot Cancer Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, 14642, USA. Rakesh_Singh@urmc.rochester.edu. [15]
DOI 10.1038/s41598-024-63392-2
PMID 38834690
发布时间 2024-06-12
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