换一批Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma.
第一作者：
Flurina A M,Saner
第一单位：
Peter MacCallum Cancer Centre, Melbourne, Australia.;Department of Obstetrics and Gynecology, Bern University Hospital and University of Bern, Bern, Switzerland.
作者：
Flurina A M,Saner [1]
;
Kazuaki,Takahashi [2]
;
Timothy,Budden [3]
;
Ahwan,Pandey [4]
;
Dinuka,Ariyaratne [4]
;
Tibor A,Zwimpfer [4]
;
Nicola S,Meagher [5]
;
Sian,Fereday [6]
;
Laura,Twomey [4]
;
Kathleen I,Pishas [6]
;
Therese,Hoang [4]
;
Adelyn,Bolithon [7]
;
Nadia,Traficante [6]
;
Australian Ovarian Cancer Study Group [6]
;
Kathryn,Alsop [6]
;
Elizabeth L,Christie [8]
;
Eun-Young,Kang [9]
;
Gregg S,Nelson [9]
;
Prafull,Ghatage [10]
;
Cheng-Han,Lee [11]
;
Marjorie J,Riggan [12]
;
Jennifer,Alsop [13]
;
Matthias W,Beckmann [14]
;
Jessica,Boros [15]
;
Alison H,Brand [16]
;
Angela,Brooks-Wilson [17]
;
Michael E,Carney [18]
;
Penny,Coulson [19]
;
Madeleine,Courtney-Brooks [20]
;
Kara L,Cushing-Haugen [21]
;
Cezary,Cybulski [22]
;
Mona A,El-Bahrawy [23]
;
Esther,Elishaev [24]
;
Ramona,Erber [25]
;
Simon A,Gayther [26]
;
Aleksandra,Gentry-Maharaj [27]
;
C Blake,Gilks [28]
;
Paul R,Harnett [29]
;
Holly R,Harris [24]
;
Arndt,Hartmann [13]
;
Alexander,Hein [4]
;
Joy,Hendley [30]
;
Brenda Y,Hernandez [31]
;
Anna,Jakubowska [32]
;
Mercedes,Jimenez-Linan [18]
;
Michael E,Jones [33]
;
Scott H,Kaufmann [14]
;
Catherine J,Kennedy [34]
;
Tomasz,Kluz [35]
;
Jennifer M,Koziak [36]
;
Björg,Kristjansdottir [37]
;
Nhu D,Le [38]
;
Marcin,Lener [39]
;
Jenny,Lester [21]
;
Jan,Lubiński [40]
;
Constantina,Mateoiu [39]
;
Sandra,Orsulic [13]
;
Matthias,Ruebner [18]
;
Minouk J,Schoemaker [12]
;
Mitul,Shah [41]
;
Raghwa,Sharma [42]
;
Mark E,Sherman [43]
;
Yurii B,Shvetsov [23]
;
T Rinda,Soong [44]
;
Helen,Steed [19]
;
Paniti,Sukumvanich [45]
;
Aline,Talhouk [19]
;
Sarah E,Taylor [46]
;
Robert A,Vierkant [47]
;
Chen,Wang [48]
;
Martin,Widschwendter [43]
;
Lynne R,Wilkens [47]
;
Stacey J,Winham [45]
;
Michael S,Anglesio [11]
;
Andrew,Berchuck [49]
;
James D,Brenton [6]
;
Ian,Campbell [50]
;
Linda S,Cook [51]
;
Jennifer A,Doherty [13]
;
Peter A,Fasching [52]
;
Renée T,Fortner [53]
;
Marc T,Goodman [21]
;
Jacek,Gronwald [54]
;
David G,Huntsman [39]
;
Beth Y,Karlan [55]
;
Linda E,Kelemen [56]
;
Usha,Menon [57]
;
Francesmary,Modugno [58]
;
Paul D P,Pharoah [59]
;
Joellen M,Schildkraut [37]
;
Karin,Sundfeldt [60]
;
Anthony J,Swerdlow [61]
;
Ellen L,Goode [62]
;
Anna,DeFazio [8]
;
Martin,Köbel [7]
;
Susan J,Ramus [6]
;
David D L,Bowtell [6]
;
Dale W,Garsed
作者单位：
Peter MacCallum Cancer Centre, Melbourne, Australia.;Department of Obstetrics and Gynecology, Bern University Hospital and University of Bern, Bern, Switzerland.
[1]
Peter MacCallum Cancer Centre, Melbourne, Australia.;Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan.
[2]
School of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, Australia.;Skin Cancer and Ageing Lab, Cancer Research United Kingdom Manchester Institute, The University of Manchester, Manchester, United Kingdom.
[3]
Peter MacCallum Cancer Centre, Melbourne, Australia.
[4]
School of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, Australia.;The Daffodil Centre, The University of Sydney, A Joint Venture with Cancer Council New South Wales, Sydney, Australia.
[5]
Peter MacCallum Cancer Centre, Melbourne, Australia.;Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia.
[6]
School of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, Australia.;Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, Australia.
[7]
Department of Pathology and Laboratory Medicine, Foothills Medical Center, University of Calgary, Calgary, Canada.
[8]
Division of Gynecologic Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Canada.
[9]
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
[10]
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina.
[11]
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
[12]
Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.
[13]
Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, Australia.;Department of Gynaecological Oncology, Westmead Hospital, Sydney, Australia.;The University of Sydney, Sydney, Australia.
[14]
Department of Gynaecological Oncology, Westmead Hospital, Sydney, Australia.;The University of Sydney, Sydney, Australia.
[15]
Canada's Michael Smith Genome Sciences Centre, Vancouver, Canada.
[16]
Department of Obstetrics and Gynecology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.
[17]
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
[18]
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
[19]
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington.
[20]
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
[21]
Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital, London, United Kingdom.
[22]
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
[23]
Institute of Pathology, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.
[24]
Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core, Cedars-Sinai Medical Center, Los Angeles, California.
[25]
MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, United Kingdom.;Department of Women's Cancer, Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, United Kingdom.
[26]
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
[27]
The University of Sydney, Sydney, Australia.;Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney, Australia.
[28]
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington.;Department of Epidemiology, University of Washington, Seattle, Washington.
[29]
University of Hawaii Cancer Center, Honolulu, Hawaii.
[30]
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.;Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland.
[31]
Department of Histopathology, Addenbrooke's Hospital, Cambridge, United Kingdom.
[32]
Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota.
[33]
Department of Gynecology and Obstetrics, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszów, Poland.
[34]
Alberta Health Services-Cancer Care, Calgary, Canada.
[35]
Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden.
[36]
Cancer Control Research, BC Cancer Agency, Vancouver, Canada.
[37]
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, Szczecin, Poland.
[38]
Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.
[39]
Department of Pathology, University of Gothenburg, Gothenburg, Sweden.
[40]
Tissue Pathology and Diagnostic Oncology, Westmead Hospital, Sydney, Australia.
[41]
Department of Health Sciences Research, Mayo Clinic, Jacksonville, Florida.
[42]
Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland.
[43]
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada.;Section of Gynecologic Oncology Surgery, North Zone, Alberta Health Services, Edmonton, Canada.
[44]
British Columbia's Gynecological Cancer Research Team (OVCARE), BC Cancer, and Vancouver General Hospital, University of British Columbia, Vancouver, Canada.;Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada.
[45]
Department of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, Minnesota.
[46]
Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota.
[47]
EUTOPS Institute, University of Innsbruck, Innsbruck, Austria.
[48]
Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
[49]
Department of Epidemiology, School of Public Health, University of Colorado, Aurora, Colorado.;Community Health Sciences, University of Calgary, Calgary, Canada.
[50]
Department of Population Health Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
[51]
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.;Department of Research, Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway.
[52]
Cancer Prevention and Control Program, Cedars-Sinai Cancer, Cedars-Sinai Medical Center, Los Angeles, California.
[53]
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.;British Columbia's Gynecological Cancer Research Team (OVCARE), BC Cancer, and Vancouver General Hospital, University of British Columbia, Vancouver, Canada.;Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada.;Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, Canada.
[54]
Division of Acute Disease Epidemiology, South Carolina Department of Health & Environmental Control, Columbia, South Carolina.
[55]
MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, United Kingdom.
[56]
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.;Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania.;Women's Cancer Research Center, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, Pennsylvania.
[57]
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.;Department of Computational Biomedicine, Cedars-Sinai Medical Center, West Hollywood, California.;Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
[58]
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
[59]
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.;Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom.
[60]
Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota.
[61]
The Daffodil Centre, The University of Sydney, A Joint Venture with Cancer Council New South Wales, Sydney, Australia.;Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, Australia.;Department of Gynaecological Oncology, Westmead Hospital, Sydney, Australia.;The University of Sydney, Sydney, Australia.
[62]
医学主题词
人类(Humans);女(雌)性(Female);卵巢肿瘤(Ovarian Neoplasms);BRCA2蛋白质(BRCA2 Protein);BRCA1蛋白质(BRCA1 Protein);囊腺癌, 浆液(Cystadenocarcinoma, Serous);视网膜母细胞瘤结合蛋白类(Retinoblastoma Binding Proteins);预后(Prognosis);泛素蛋白连接酶类(Ubiquitin-Protein Ligases);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);中年人(Middle Aged);生殖细胞系突变(Germ-Line Mutation);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);老年人(Aged);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes)
DOI
10.1158/1078-0432.CCR-23-3552
PMID
38837893
发布时间
2025-07-21
基金项目
P2BEP3-172246/Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF)
::Swedish Cancer Foundation::
MCRF22018/Victorian Cancer Agency (VCA)
::Foundation for Clinical-Experimental Cancer Research::
R01CA172404/National Cancer Institute (NCI)
UL1 TR000124/TR/NCATS NIH HHS/United States
742432/HORIZON EUROPE European Research Council (ERC)
1186505/National Health and Medical Research Council (NHMRC)
2009840/National Health and Medical Research Council (NHMRC)
18274/Michael Smith Health Research BC (MSFHR)
P30 CA015083/CA/NCI NIH HHS/United States
W81XWH-16-2-0010/U.S. Army Medical Research and Development Command (MRDC)
UL1 TR001881/TR/NCATS NIH HHS/United States
BIL KFS-3942-08-2016/Krebsliga Schweiz (Swiss Cancer League)
MCRF21004/Victorian Cancer Agency (VCA)
APP1111032/National Health and Medical Research Council (NHMRC)
R01 CA172404/CA/NCI NIH HHS/United States
1092856/National Health and Medical Research Council (NHMRC)
::Janet D. Cottrelle Foundation (JDCF)::
W81XWH-21-1-0401/U.S. Army Medical Research and Development Command (MRDC)
R01 CA248288/CA/NCI NIH HHS/United States
P30 CA071789/CA/NCI NIH HHS/United States
P50 CA136393/CA/NCI NIH HHS/United States
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