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Gene regulatory network topology governs resistance and treatment escape in glioma stem-like cells.

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第一作者： James H,Park

第一单位： Institute for Systems Biology, Seattle, WA, USA.

作者： James H,Park ^[1] ; Parvinder,Hothi ^[2] ; Adrian Lopez Garcia,de Lomana ^[3] ; Min,Pan ^[1] ; Rachel,Calder ^[1] ; Serdar,Turkarslan ^[1] ; Wei-Ju,Wu ^[1] ; Hwahyung,Lee ^[2] ; Anoop P,Patel ^[4] ; Charles,Cobbs ^[2] ; Sui,Huang ^[1] ; Nitin S,Baliga ^[5]

作者单位： Institute for Systems Biology, Seattle, WA, USA. ^[1] Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA, USA. ^[2] Center for Systems Biology, University of Iceland, Reykjavik, Iceland. ^[3] Department of Neurosurgery, Preston Robert Tisch Brain Tumor Center, Duke University, Durham, NC, USA.;Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA. ^[4] Institute for Systems Biology, Seattle, WA, USA.;Departments of Microbiology, Biology, and Molecular Engineering Sciences, University of Washington, Seattle, WA, USA. ^[5]

医学主题词人类(Humans);肿瘤干细胞(Neoplastic Stem Cells);基因调控网络(Gene Regulatory Networks);抗药性, 肿瘤(Drug Resistance, Neoplasm);神经胶质瘤(Glioma);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);脑肿瘤(Brain Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);胶质母细胞瘤(Glioblastoma)

DOI 10.1126/sciadv.adj7706

PMID 38848360

发布时间 2025-06-23

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