Potency and efficacy of pharmacological PIP4K2 inhibitors in acute lymphoblastic leukemia.

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第一作者： Keli,Lima

第一单位： Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil; Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: kelilima@usp.br.

作者： Keli,Lima ^[1] ; Frederico Lisboa,Nogueira ^[2] ; Marcella,Cipelli ^[3] ; Maria Fernanda Lopes,Carvalho ^[4] ; Diego Antonio,Pereira-Martins ^[5] ; Wellington Fernandes,da Silva ^[2] ; Rita de Cássia,Cavaglieri ^[2] ; Luciana,Nardinelli ^[2] ; Aline de Medeiros,Leal ^[2] ; Elvira Deolinda Rodrigues Pereira,Velloso ^[2] ; Israel,Bendit ^[2] ; Niels Olsen Saraiva,Câmara ^[3] ; Jan Jacob,Schuringa ^[6] ; João Agostinho,Machado-Neto ^[7] ; Eduardo Magalhães,Rego ^[8]

作者单位： Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil; Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: kelilima@usp.br. ^[1] Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil. ^[2] Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. ^[3] Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. ^[4] Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil; Department of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. ^[5] Department of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. ^[6] Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: jamachadoneto@usp.br. ^[7] Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil. Electronic address: eduardo.rego@fm.usp.br. ^[8]

关键词 Acute lymphoblastic leukemia Antineoplastic agents Drug development Phosphatidylinositol 5-phosphate 4-kinase type 2