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Genome-wide association studies with experimental validation identify a protective role for B lymphocytes against chronic post-surgical pain.

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作者单位: Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthesia, Faculty of Medicine, Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada. [1] Department of Anesthesiology and Pain Management, Maastricht University Medical Center+, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, University of Maastricht, Maastricht, The Netherlands. [2] Department of Pharmacology and Toxicology and Translational Research Initiative for Pain and Neuropathy, Virginia Commonwealth University, Richmond, VA, USA. [3] Department of Anesthesiology, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada; Department of Biomedical & Molecular Sciences, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada. [4] Department of Biomedical & Molecular Sciences, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada. [5] Department of Microbiology and Immunology, Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada. [6] Department of Pain Therapy, Ensemble Hospitalier de la Côte, Morges, Switzerland. [7] Pain Therapy Service, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. [8] Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. [9] College of Nursing, University of Iowa, Iowa City, IA, USA. [10] Department of Anesthesiology, Centre for Cancer and Organ Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. [11] Section of Surgical Pathophysiology 7621, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. [12] Department of Anesthesiology, Division of Anesthesiology, Emergency and Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. [13] Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA. [14] Department of Microbiology and Immunology, Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada; McGill Interdisciplinary Initiative in Infection and Immunity, McGill Centre for Microbiome Research, Montreal, QC, Canada. [15] Department of Psychology, Faculty of Science, Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada. [16] Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthesia, Faculty of Medicine, Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada. Electronic address: luda.diatchenko@mcgill.ca. [17]
DOI 10.1016/j.bja.2024.04.053
PMID 38862382
发布时间 2024-07-29
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British journal of anaesthesia

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