换一批
换一批Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight.
作者：
JangKeun,Kim [1]
;
Braden T,Tierney [2]
;
Eliah G,Overbey [1]
;
Ezequiel,Dantas [2]
;
Matias,Fuentealba [1]
;
Jiwoon,Park [2]
;
S Anand,Narayanan [3]
;
Fei,Wu [4]
;
Deena,Najjar [5]
;
Christopher R,Chin [6]
;
Cem,Meydan [7]
;
Conor,Loy [1]
;
Begum,Mathyk [2]
;
Remi,Klotz [8]
;
Veronica,Ortiz [7]
;
Khiem,Nguyen [1]
;
Krista A,Ryon [2]
;
Namita,Damle [9]
;
Nadia,Houerbi [1]
;
Laura I,Patras [2]
;
Nathan,Schanzer [10]
;
Gwyneth A,Hutchinson [11]
;
Jonathan,Foox [12]
;
Chandrima,Bhattacharya [13]
;
Matthew,Mackay [13]
;
Evan E,Afshin [7]
;
Jeremy Wain,Hirschberg [1]
;
Ashley S,Kleinman [1]
;
Julian C,Schmidt [1]
;
Caleb M,Schmidt [2]
;
Michael A,Schmidt [14]
;
Afshin,Beheshti [15]
;
Irina,Matei [16]
;
David,Lyden [17]
;
Sean,Mullane [18]
;
Amran,Asadi [19]
;
Joan S,Lenz [1]
;
Omary,Mzava [2]
;
Min,Yu [2]
;
Saravanan,Ganesan [9]
;
Iwijn,De Vlaminck [9]
;
Ari M,Melnick [1]
;
Darko,Barisic [2]
;
Daniel A,Winer [1]
;
Sara R,Zwart [2]
;
Brian E,Crucian [1]
;
Scott M,Smith [2]
;
Jaime,Mateus [20]
;
David,Furman [21]
;
Christopher E,Mason [20]
作者单位：
Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 100221, USA.
[1]
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, 10021, USA.
[2]
Center for STEM, University of Austin, Austin, TX, USA.
[3]
BioAstra, Inc, New York, NY, USA.
[4]
Division of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA.
[5]
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, 10065, USA.
[6]
Buck Artificial Intelligence Platform, Buck Institute for Research on Aging, Novato, CA, 94945, USA.
[7]
Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.
[8]
Tri-Institutional Biology and Medicine Program, Weill Cornell Medicine, New York, NY, 10021, USA.
[9]
Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
[10]
Cornell University, Meinig School of Biomedical Engineering, Ithaca, NY, 14850, USA.
[11]
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
[12]
Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
[13]
Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
[14]
Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania.
[15]
School of Medicine, New York Medical College, Valhalla, NY, 10595, USA.
[16]
NASA Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, 94720, USA.
[17]
Department of Bioengineering, University of California, Berkeley, Berkeley, CA, 94720, USA.
[18]
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA.
[19]
Sovaris Aerospace, Boulder, CO, USA.
[20]
Advanced Pattern Analysis & Human Performance Group, Boulder, CO, USA.
[21]
Department of Systems Engineering, Colorado State University, Fort Collins, CO, USA.
[22]
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
[23]
Blue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, 94035, USA.
[24]
Space Exploration Technologies Corporation (SpaceX), Hawthorne, CA, USA.
[25]
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
[26]
Department of Immunology, University of Toronto, Toronto, ON, M5S 1A8, Canada.
[27]
Division of Cellular & Molecular Biology, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON, M5G 1L7, Canada.
[28]
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5S 1A8, Canada.
[29]
University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA.
[30]
Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Human Health and Performance Directorate, 2101 NASA Parkway, Houston, TX, 77058, USA.
[31]
Buck Artificial Intelligence Platform, Buck Institute for Research on Aging, Novato, CA, 94945, USA. dfurman@buckinstitute.org.
[32]
Stanford 1000 Immunomes Project, Stanford School of Medicine, Stanford, CA, 94306, USA. dfurman@buckinstitute.org.
[33]
Instituto de Investigaciones en Medicina Traslacional (IIMT), Universidad Austral, CONICET, Pilar, Argentina. dfurman@buckinstitute.org.
[34]
Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 100221, USA. chm2042@med.cornell.edu.
[35]
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, 10021, USA. chm2042@med.cornell.edu.
[36]
Tri-Institutional Biology and Medicine Program, Weill Cornell Medicine, New York, NY, 10021, USA. chm2042@med.cornell.edu.
[37]
The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, 10021, USA. chm2042@med.cornell.edu.
[38]
WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, 10021, USA. chm2042@med.cornell.edu.
[39]
主题词
宇宙飞行(Space Flight);动物(Animals);女(雌)性(Female);男(雄)性(Male);单细胞分析(Single-Cell Analysis);人类(Humans);小鼠(Mice);宇航员(Astronauts);细胞因子类(Cytokines);T淋巴细胞(T-Lymphocytes);性别因素(Sex Factors);基因表达谱(Gene Expression Profiling);氧化磷酸化(Oxidative Phosphorylation)
DOI
10.1038/s41467-024-49211-2
PMID
38862516
发布时间
2024-06-25
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Nature communications
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