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An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing.

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第一作者： Amanda L,Waterbury

第一单位： Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

作者： Amanda L,Waterbury ^[1] ; Hui Si,Kwok ^[1] ; Ceejay,Lee ^[1] ; Domenic N,Narducci ^[2] ; Allyson M,Freedy ^[1] ; Cindy,Su ^[1] ; Shaunak,Raval ^[3] ; Andrew H,Reiter ^[3] ; William,Hawkins ^[3] ; Kwangwoon,Lee ^[4] ; Jiaming,Li ^[1] ; Samuel M,Hoenig ^[1] ; Michael E,Vinyard ^[3] ; Philip A,Cole ^[4] ; Anders S,Hansen ^[2] ; Steven A,Carr ^[3] ; Malvina,Papanastasiou ^[3] ; Brian B,Liau ^[5]

作者单位： Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. ^[1] Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA. ^[2] Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. ^[3] Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. ^[4] Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: liau@chemistry.harvard.edu. ^[5]

关键词 autoinhibitory switch condensate intrinsically disordered region leukemic differentiation transcription factors transcriptional corepressor

医学主题词组蛋白脱甲基酶类(Histone Demethylases);人类(Humans);增强子元件, 遗传学(Enhancer Elements, Genetic);转录因子(Transcription Factors);动物(Animals);蛋白质结合(Protein Binding);小鼠(Mice);细胞分化(Cell Differentiation);基因沉默(Gene Silencing)

DOI 10.1016/j.molcel.2024.05.017

PMID 38870936

发布时间 2025-06-21

基金项目

R01 CA274437/CA/NCI NIH HHS/United States UM1 HG011536/HG/NHGRI NIH HHS/United States DP2 GM140938/GM/NIGMS NIH HHS/United States DP2 GM137494/GM/NIGMS NIH HHS/United States R35 GM149229/GM/NIGMS NIH HHS/United States

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