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Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling.

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第一作者： Sebastijan,Hobor

第一单位： Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.

作者： Sebastijan,Hobor ^[1] ; Maise,Al Bakir ^[1] ; Crispin T,Hiley ^[2] ; Marcin,Skrzypski ^[3] ; Alexander M,Frankell ^[4] ; Bjorn,Bakker ^[5] ; Thomas B K,Watkins ^[1] ; Aleksandra,Markovets ^[6] ; Jonathan R,Dry ^[7] ; Andrew P,Brown ^[7] ; Jasper,van der Aart ^[8] ; Hilda,van den Bos ^[9] ; Diana,Spierings ^[9] ; Dahmane,Oukrif ^[10] ; Marco,Novelli ^[10] ; Turja,Chakrabarti ^[11] ; Adam H,Rabinowitz ^[12] ; Laila,Ait Hassou ^[13] ; Saskia,Litière ^[14] ; D Lucas,Kerr ^[11] ; Lisa,Tan ^[11] ; Gavin,Kelly ^[14] ; David A,Moore ^[15] ; Matthew J,Renshaw ^[16] ; Subramanian,Venkatesan ^[1] ; William,Hill ^[1] ; Ariana,Huebner ^[17] ; Carlos,Martínez-Ruiz ^[18] ; James R M,Black ^[18] ; Wei,Wu ^[11] ; Mihaela,Angelova ^[1] ; Nicholas,McGranahan ^[18] ; Julian,Downward ^[19] ; Juliann,Chmielecki ^[7] ; Carl,Barrett ^[7] ; Kevin,Litchfield ^[1] ; Su Kit,Chew ^[4] ; Collin M,Blakely ^[11] ; Elza C,de Bruin ^[8] ; Floris,Foijer ^[9] ; Karen H,Vousden ^[20] ; Trever G,Bivona ^[21] ; TRACERx consortium ^[4] ; Robert E,Hynds ^[22] ; Nnennaya,Kanu ^[23] ; Simone,Zaccaria ^[24] ; Eva,Grönroos ^[25] ; Charles,Swanton

作者单位： Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK. ^[1] Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.;Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.;Department of Medical Oncology, University College London Hospitals, 235 Euston Rd, Fitzrovia, London, NW1 2BU, UK. ^[2] Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.;Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.;Department of Medical Oncology, University College London Hospitals, 235 Euston Rd, Fitzrovia, London, NW1 2BU, UK.;Department of Oncology and Radiotherapy, Medical University of Gdańsk, ul. Mariana Smoluchowskiego 17, 80-214, Gdańsk, Poland. ^[3] Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.;Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK. ^[4] Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.;European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, Groningen, 9713, the Netherlands. ^[5] Oncology Data Science, Oncology R&D, AstraZeneca, Boston, MA, USA. ^[6] Late Development, Oncology R&D, AstraZeneca, Boston, MA, USA. ^[7] Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK. ^[8] European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, Groningen, 9713, the Netherlands. ^[9] Research Department of Pathology, University College London Medical School, University Street, London, WC1E 6JJ, UK. ^[10] Department of Medicine, University of California, San Francisco, CA, 94158, USA. ^[11] Furlong Laboratory, EMBL Meyerhofstraße 1, 69117, Heidelberg, Germany. ^[12] European Organization for Research and Treatment of Cancer, Brussels, Belgium. ^[13] Bioinformatics & Biostatistics; Francis Crick Institute, London, UK. ^[14] Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.;Department of Cellular Pathology, University College London Hospitals, London, UK. ^[15] Advanced Light Microscopy, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK. ^[16] Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.;Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.;Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. ^[17] Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.;Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. ^[18] Oncogene Biology Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK. ^[19] p53 and Metabolism Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK. ^[20] Department of Medicine, University of California, San Francisco, CA, 94158, USA.;Chan-Zuckerberg Biohub, San Francisco, USA. ^[21] Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK. n.kanu@ucl.ac.uk. ^[22] Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK. s.zaccaria@ucl.ac.uk.;Computational Cancer Genomics Research Group, University College London Cancer Institute, London, UK. s.zaccaria@ucl.ac.uk. ^[23] Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK. Eva.Gronroos@crick.ac.uk. ^[24] Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK. Charles.Swanton@crick.ac.uk.;Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK. Charles.Swanton@crick.ac.uk.;Department of Medical Oncology, University College London Hospitals, 235 Euston Rd, Fitzrovia, London, NW1 2BU, UK. Charles.Swanton@crick.ac.uk. ^[25]