Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.

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第一作者： Peng,Zhang

第一单位： State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.

作者： Peng,Zhang ^[1] ; Xiaoqing,Hu ^[1] ; Zekun,Li ^[1] ; Qian,Liu ^[1] ; Lele,Liu ^[1] ; Yingying,Jin ^[1] ; Sizhe,Liu ^[1] ; Xiang,Zhao ^[1] ; Jianqiao,Wang ^[1] ; Delong,Hao ^[1] ; Houzao,Chen ^[1] ; Depei,Liu ^[2]

作者单位： State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China. ^[1] State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.;Haihe Laboratory of Cell Ecosystem, Tianjin 300301, China. ^[2]

主题词动物(Animals);女(雌)性(Female);人类(Humans);男(雄)性(Male);小鼠(Mice);DNA, 单链(DNA, Single-Stranded);HEK293细胞(HEK293 Cells);免疫, 先天(Immunity, Innate);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);核蛋白质类(Nuclear Proteins);核糖核酸酶类(Ribonucleases)

DOI 10.1126/sciimmunol.adj5465

PMID 38875319

发布时间 2024-06-27

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Science immunology

2024年9卷96期

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Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.

Science immunology

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Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.

Science immunology

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Science immunology

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