首页> Cancer chemotherapy and pharmacology> Population pharmacokinetics of TLD-1, a novel liposomal doxorubicin, in a phase I trial.

Population pharmacokinetics of TLD-1, a novel liposomal doxorubicin, in a phase I trial.

导出 OA

翻译打印收藏纠错

第一作者： Anna M,Mc Laughlin

第一单位： Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Kelchstr. 31, 12169, Berlin, Germany.;Graduate Research Training Program PharMetrX, Freie Universitaet Berlin/University of Potsdam, Berlin/Potsdam, Germany.

作者： Anna M,Mc Laughlin ^[1] ; Dagmar,Hess ^[2] ; Robin,Michelet ^[3] ; Ilaria,Colombo ^[4] ; Simon,Haefliger ^[5] ; Sara,Bastian ^[6] ; Manuela,Rabaglio ^[5] ; Michael,Schwitter ^[7] ; Stefanie,Fischer ^[2] ; Katrin,Eckhardt ^[8] ; Stefanie,Hayoz ^[8] ; Christoph,Kopp ^[8] ; Marian,Klose ^[1] ; Cristiana,Sessa ^[4] ; Anastasios,Stathis ^[9] ; Stefan,Halbherr ^[10] ; Wilhelm,Huisinga ^[11] ; Markus,Joerger ^[12] ; Charlotte,Kloft ^[13]

作者单位： Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Kelchstr. 31, 12169, Berlin, Germany.;Graduate Research Training Program PharMetrX, Freie Universitaet Berlin/University of Potsdam, Berlin/Potsdam, Germany. ^[1] Department of Medical Oncology and Haematology, Cantonal Hospital St. Gallen, Rorschacher Strasse 95, 9007, St. Gallen, Switzerland. ^[2] Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Kelchstr. 31, 12169, Berlin, Germany. ^[3] Department of Medical Oncology, Oncology Institute of Southern Switzerland, EOC, Bellinzona, Switzerland. ^[4] Department of Medical Oncology, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland. ^[5] Department of Medical Oncology, Kantonsspital Graubünden, Chur, Switzerland. ^[6] Oncology/Hematology, Kantonsspital Graubünden, Chur, Switzerland. ^[7] Coordinating Center, Swiss Group for Clinical Cancer Research, Bern, Switzerland. ^[8] Oncology Institute of Southern Switzerland, EOC, Bellinzona, Switzerland.;Faculty of Biomedical Sciences, Universita della Svizzera Italiana, Lugano, Switzerland. ^[9] Innomedica Switzerland AG, Bern, Switzerland. ^[10] Institute of Mathematics, University of Potsdam, Potsdam, Germany. ^[11] Department of Medical Oncology and Haematology, Cantonal Hospital St. Gallen, Rorschacher Strasse 95, 9007, St. Gallen, Switzerland. markus.joerger@kssg.ch. ^[12] Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Kelchstr. 31, 12169, Berlin, Germany. charlotte.kloft@fu-berlin.de. ^[13]

关键词 Doxorubicin Liposomes Nanoparticles Nonlinear mixed-effects model Pharmacokinetics Pharmacometrics