Remdesivir ameliorates ulcerative colitis-propelled cell inflammation and pyroptosis in acetic acid rats by restoring SIRT6/FoxC1 pathway.

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第一作者： Mamdouh A,Oraby

第一单位： Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt. Electronic address: Mamahmed23@gmail.com.

作者： Mamdouh A,Oraby ^[1] ; Sherif S,Abdel Mageed ^[2] ; Ahmed,Amr Raouf ^[3] ; Dareen A,Abdelshafy ^[4] ; Eman F,Ahmed ^[4] ; Rowida T,Khalil ^[4] ; Safwat A,Mangoura ^[5] ; Doaa S,Fadaly ^[6]

作者单位： Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt. Electronic address: Mamahmed23@gmail.com. ^[1] Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt. Electronic address: Sherif.abdelmeguid@buc.edu.eg. ^[2] Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt. Electronic address: ahmed.amr@buc.edu.eg. ^[3] Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt. ^[4] Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt. Electronic address: Safwat-Abdelhady@buc.edu.eg. ^[5] Department of Clinical Pharmacology, Faculty of Medicine, Zagazig University, Zagazig, Egypt. Electronic address: DSEid@medicine.zu.edu.eg. ^[6]

关键词 Inflammation Pyroptosis Remdesivir SIRT6/FoxC1 Ulcerative colitis