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nCas9 Engineering for Improved Target Interaction Presents an Effective Strategy to Enhance Base Editing.

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第一作者： Guiquan,Zhang

第一单位： Zhejiang Lab, Hangzhou, Zhejiang, 311121, China.

作者： Guiquan,Zhang ^[1] ; Ziguo,Song ^[2] ; Shisheng,Huang ^[1] ; Yafeng,Wang ^[3] ; Jiayuan,Sun ^[2] ; Lu,Qiao ^[1] ; Guanglei,Li ^[4] ; Yuanyuan,Feng ^[1] ; Wei,Han ^[1] ; Jin,Tang ^[1] ; Yulin,Chen ^[2] ; Xingxu,Huang ^[1] ; Furui,Liu ^[1] ; Xiaolong,Wang ^[2] ; Jianghuai,Liu ^[5]

作者单位： Zhejiang Lab, Hangzhou, Zhejiang, 311121, China. ^[1] International Joint Agriculture Research Center for Animal Bio-Breeding, Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China. ^[2] Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China. ^[3] Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, 100 Haike Rd., Pudong New Area, Shanghai, 201210, China. ^[4] State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center at Medical School of Nanjing University, Nanjing, 210061, China. ^[5]

关键词 T‐cells base editor enhanced BE nCas9 engineering non‐targeted strand

医学主题词人类(Humans);HEK293细胞(HEK293 Cells)

DOI 10.1002/advs.202405426

PMID 38881503

发布时间 2024-08-23

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