Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC.

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作者： Lixuan,Wang ^[1] ; Rongchun,Yang ^[2] ; Yue,Kong ^[3] ; Jing,Zhou ^[1] ; Yingyao,Chen ^[2] ; Rui,Li ^[3] ; Chuwen,Chen ^[1] ; Xinran,Tang ^[2] ; Xiaobing,Chen ^[3] ; Juan,Xia ^[1] ; Xijuan,Chen ^[2] ; Bin,Cheng ^[3] ; Xianyue,Ren ^[1]

作者单位： Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, China. ^[1] Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China. ^[2] Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, China. ^[3] Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China. ^[4] Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, China. chengbin@mail.sysu.edu.cn. ^[5] Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China. chengbin@mail.sysu.edu.cn. ^[6] Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, China. chengbin@mail.sysu.edu.cn. ^[7] Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, China. renxy7@mail.sysu.edu.cn. ^[8] Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China. renxy7@mail.sysu.edu.cn. ^[9] Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, China. renxy7@mail.sysu.edu.cn. ^[10]

主题词人类(Humans);预后(Prognosis);丝氨酸(Serine);头颈部肿瘤(Head and Neck Neoplasms);单细胞分析(Single-Cell Analysis);甘氨酸(Glycine);碳(Carbon);肿瘤微环境(Tumor Microenvironment);细胞增殖(Cell Proliferation);细胞系, 肿瘤(Cell Line, Tumor);动物(Animals)

DOI 10.1038/s41368-024-00310-2

PMID 38886346

发布时间 2024-06-20

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International journal of oral science

2024年16卷1期

44页

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Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC.

International journal of oral science

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International journal of oral science

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Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC.

International journal of oral science

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International journal of oral science

相关期刊

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