Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT<sub>2A</sub> receptor activation.

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第一作者： Hugo R,Arias

第一单位： Department of Pharmacology and Physiology, College of Osteopathic Medicine, Oklahoma State University Center for Health Sciences, Tahlequah, OK, USA.

作者： Hugo R,Arias ^[1] ; Laura,Micheli ^[2] ; Deborah,Rudin ^[3] ; Ophelie,Bento ^[4] ; Saskia,Borsdorf ^[5] ; Clara,Ciampi ^[6] ; Philippe,Marin ^[4] ; Evgeni,Ponimaskin ^[5] ; Dina,Manetti ^[7] ; Maria Novella,Romanelli ^[7] ; Carla,Ghelardini ^[6] ; Matthias E,Liechti ^[3] ; Lorenzo,Di Cesare Mannelli ^[6]

作者单位： Department of Pharmacology and Physiology, College of Osteopathic Medicine, Oklahoma State University Center for Health Sciences, Tahlequah, OK, USA. ^[1] Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, Florence, Italy. Electronic address: laura.micheli@unifi.it. ^[2] Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland; Division of Clinical Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. ^[3] Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France. ^[4] Cellular Neurophysiology, Hannover Medical School, Hannover, Germany. ^[5] Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, Florence, Italy. ^[6] Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy. ^[7]

关键词 5-HT(2A)5-HT(6)Visceral pain agonist and reverse agonist and 5-HT(7) receptors ibogalogs neuropathic pain