Unraveling Verapamil's Multidimensional Role in Diabetes Therapy: From β-Cell Regeneration to Cholecystokinin Induction in Zebrafish and MIN6 Cell-Line Models.

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第一作者： Hossein,Arefanian

第一单位： Department of Immunology & Microbiology, Dasman Diabetes Institute, Dasman 15462, Kuwait.

作者： Hossein,Arefanian ^[1] ; Ashraf,Al Madhoun ^[2] ; Fatema,Al-Rashed ^[1] ; Fawaz,Alzaid ^[3] ; Fatemah,Bahman ^[1] ; Rasheeba,Nizam ^[4] ; Mohammed,Alhusayan ^[5] ; Sumi,John ^[4] ; Sindhu,Jacob ^[4] ; Michayla R,Williams ^[5] ; Nermeen,Abukhalaf ^[6] ; Steve,Shenouda ^[1] ; Shibu,Joseph ^[7] ; Halemah,AlSaeed ^[1] ; Shihab,Kochumon ^[1] ; Anwar,Mohammad ^[8] ; Lubaina,Koti ^[4] ; Sardar,Sindhu ^[9] ; Mohamed,Abu-Farha ^[10] ; Jehad,Abubaker ^[8] ; Thangavel Alphonse,Thanaraj ^[4] ; Rasheed,Ahmad ^[1] ; Fahd,Al-Mulla ^[4]

作者单位： Department of Immunology & Microbiology, Dasman Diabetes Institute, Dasman 15462, Kuwait. ^[1] Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Dasman 15462, Kuwait.;Animal and Imaging Core Facility, Dasman Diabetes Institute, Dasman 15462, Kuwait. ^[2] Department of Bioenergetics & Neurometabolism, Dasman Diabetes Institute, Dasman 15462, Kuwait.;Institut Necker Enfants Malades (INEM), French Institute of Health and Medical Research (INSERM), Immunity & Metabolism of Diabetes (IMMEDIAB), Université de Paris Cité, 75014 Paris, France. ^[3] Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Dasman 15462, Kuwait. ^[4] Department of Bioenergetics & Neurometabolism, Dasman Diabetes Institute, Dasman 15462, Kuwait. ^[5] Animal and Imaging Core Facility, Dasman Diabetes Institute, Dasman 15462, Kuwait. ^[6] Special Services Facilities, Dasman Diabetes Institute, Dasman 15462, Kuwait. ^[7] Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman 15462, Kuwait. ^[8] Department of Immunology & Microbiology, Dasman Diabetes Institute, Dasman 15462, Kuwait.;Animal and Imaging Core Facility, Dasman Diabetes Institute, Dasman 15462, Kuwait. ^[9] Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Dasman 15462, Kuwait.;Department of Translational Research, Dasman Diabetes Institute, Dasman 15462, Kuwait. ^[10]

关键词 MIN6 cells calcium channel blocker diabetes mellitus verapamil zebrafish β-cells

主题词动物(Animals);小鼠(Mice);细胞系(Cell Line);细胞增殖(Cell Proliferation);胆囊收缩素(Cholecystokinin);疾病模型, 动物(Disease Models, Animal);葡萄糖(Glucose);胰岛素(Insulin);胰岛素分泌细胞(Insulin-Secreting Cells);再生(Regeneration);维拉帕米(Verapamil);斑马鱼(Zebrafish)

DOI 10.3390/cells13110949

PMID 38891081

发布时间 2025-01-21

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2024年13卷11期

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Unraveling Verapamil's Multidimensional Role in Diabetes Therapy: From β-Cell Regeneration to Cholecystokinin Induction in Zebrafish and MIN6 Cell-Line Models.

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Unraveling Verapamil's Multidimensional Role in Diabetes Therapy: From β-Cell Regeneration to Cholecystokinin Induction in Zebrafish and MIN6 Cell-Line Models.

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