BICC1 drives pancreatic cancer stemness and chemoresistance by facilitating tryptophan metabolism.

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第一作者： Huizhi,Sun

第一单位： Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Key Laboratory of Digestive Cancer, Tianjin, P. R. China.

作者： Huizhi,Sun ^[1] ; Hui,Li ^[1] ; Yuqi,Guan ^[1] ; Yudong,Yuan ^[1] ; Chao,Xu ^[1] ; Danqi,Fu ^[1] ; Peng,Xie ^[1] ; Jianming,Li ^[1] ; Tiansuo,Zhao ^[1] ; Xiuchao,Wang ^[1] ; Yukuan,Feng ^[1] ; Hongwei,Wang ^[1] ; Song,Gao ^[1] ; Shengyu,Yang ^[2] ; Yi,Shi ^[3] ; Jing,Liu ^[4] ; Antao,Chang ^[1] ; Chongbiao,Huang ^[1] ; Jihui,Hao ^[1]

作者单位： Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Key Laboratory of Digestive Cancer, Tianjin, P. R. China. ^[1] Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, USA. ^[2] Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, School of Medicine, Nankai University, Tianjin, P. R. China. ^[3] Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Key Laboratory of Digestive Cancer, Tianjin, P. R. China.;Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, P. R. China. ^[4]

主题词色氨酸(Tryptophan);人类(Humans);抗药性, 肿瘤(Drug Resistance, Neoplasm);肿瘤干细胞(Neoplastic Stem Cells);胰腺肿瘤(Pancreatic Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);动物(Animals);小鼠(Mice);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);癌, 胰腺管(Carcinoma, Pancreatic Ductal);脱氧胞苷(Deoxycytidine);RNA结合蛋白质类(RNA-Binding Proteins);吲哚胺-吡咯2,3-双加氧酶(Indoleamine-Pyrrole 2,3,-Dioxygenase)

DOI 10.1126/sciadv.adj8650

PMID 38896624

发布时间 2024-12-16

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Science advances

2024年10卷25期

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BICC1 drives pancreatic cancer stemness and chemoresistance by facilitating tryptophan metabolism.

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BICC1 drives pancreatic cancer stemness and chemoresistance by facilitating tryptophan metabolism.

Science advances

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