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Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.

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作者: Jian,Zhou [1] ; Lifang,Zhang [1] ; Jianhua,Peng [2] ; Xianhui,Zhang [3] ; Fan,Zhang [1] ; Yuanyuan,Wu [3] ; An,Huang [3] ; Fengling,Du [4] ; Yuyan,Liao [5] ; Yijing,He [3] ; Yuke,Xie [3] ; Long,Gu [3] ; Chenghao,Kuang [3] ; Wei,Ou [6] ; Maodi,Xie [6] ; Tianqi,Tu [5] ; Jinwei,Pang [5] ; Dingkun,Zhang [7] ; Kecheng,Guo [3] ; Yue,Feng [8] ; Shigang,Yin [9] ; Yang,Cao [10] ; Tao,Li [11] ; Yong,Jiang [12]
作者单位: Department of Neurosurgery, the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China; Sichuan Clinical Research Center for Neurosurgery, the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China. [1] Department of Neurosurgery, the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China; Institute of Epigenetics and Brain Science, Southwest Medical University, Luzhou 646000, China; Academician (Expert) Workstation of Sichuan Province, the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China. [2] Laboratory of Neurological Diseases and Brain Function, the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China. [3] Department of Neonatology, the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China. [4] Department of Neurosurgery, the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China. [5] Department of Anesthesiology, Laboratory of Mitochondrial Metabolism and Perioperative Medicine, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China. [6] Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China. [7] Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Department of Nuclear Medicine, the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China. [8] Institute of Epigenetics and Brain Science, Southwest Medical University, Luzhou 646000, China; Laboratory of Neurological Diseases and Brain Function, the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China. [9] Department of Cardiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China; School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address: yangcao208@ustc.edu.cn. [10] Department of Anesthesiology, Laboratory of Mitochondrial Metabolism and Perioperative Medicine, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: scutaoli1981@scu.edu.cn. [11] Department of Neurosurgery, the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China; Institute of Epigenetics and Brain Science, Southwest Medical University, Luzhou 646000, China; Laboratory of Neurological Diseases and Brain Function, the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China. Electronic address: jiangyong@swmu.edu.cn. [12]
DOI 10.1016/j.cmet.2024.05.016
PMID 38906140
发布时间 2024-09-05
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