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Network-driven cancer cell avatars for combination discovery and biomarker identification for DNA damage response inhibitors.

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第一作者： Orsolya,Papp

第一单位： Turbine Simulated Cell Technologies, Budapest, Hungary.

作者： Orsolya,Papp ^[1] ; Viktória,Jordán ^[1] ; Szabolcs,Hetey ^[1] ; Róbert,Balázs ^[1] ; Valér,Kaszás ^[1] ; Árpád,Bartha ^[1] ; Nóra N,Ordasi ^[1] ; Sebestyén,Kamp ^[1] ; Bálint,Farkas ^[1] ; Jerome,Mettetal ^[2] ; Jonathan R,Dry ^[3] ; Duncan,Young ^[4] ; Ben,Sidders ^[5] ; Krishna C,Bulusu ^[5] ; Daniel V,Veres ^[6]

作者单位： Turbine Simulated Cell Technologies, Budapest, Hungary. ^[1] Oncology Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Waltham, MA, USA. ^[2] Early Data Science, Oncology Data Science, Oncology R&D, AstraZeneca, Waltham, MA, USA. ^[3] Search and Evaluation, Oncology R&D, AstraZeneca, Cambridge, UK. ^[4] Early Data Science, Oncology Data Science, Oncology R&D, AstraZeneca, Cambridge, UK. ^[5] Turbine Simulated Cell Technologies, Budapest, Hungary. daniel.veres@turbine.ai. ^[6]

医学主题词人类(Humans);抗肿瘤药(Antineoplastic Agents);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);细胞系, 肿瘤(Cell Line, Tumor);计算机模拟(Computer Simulation);DNA损伤(DNA Damage);药物发现(Drug Discovery);药物协同作用(Drug Synergism);肿瘤(Neoplasms);信号传导(Signal Transduction);系统生物学(Systems Biology)

DOI 10.1038/s41540-024-00394-w

PMID 38906870

发布时间 2024-08-10

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NPJ systems biology and applications

2024年10卷1期

68页

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NPJ systems biology and applications

2024年10卷1期

68页

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Network-driven cancer cell avatars for combination discovery and biomarker identification for DNA damage response inhibitors.

NPJ systems biology and applications

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Network-driven cancer cell avatars for combination discovery and biomarker identification for DNA damage response inhibitors.

NPJ systems biology and applications

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NPJ systems biology and applications

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