MiR-223 enhances lipophagy by suppressing CTSB in microglia following lysolecithin-induced demyelination in mice.

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作者： Hao,Ma ^[1] ; Zhi-Lin,Ou ^[1] ; Nima,Alaeiilkhchi ^[2] ; Yong-Quan,Cheng ^[1] ; Kai,Chen ^[3] ; Jia-Yu,Chen ^[1] ; Ru-Qin,Guo ^[1] ; Min-Yue,He ^[4] ; Shi-Yi,Tang ^[4] ; Xin,Zhang ^[5] ; Zhi-Ping,Huang ^[1] ; Junhao,Liu ^[6] ; Jie,Liu ^[7] ; Qing-An,Zhu ^[1] ; Zu-Cheng,Huang ^[8] ; Hui,Jiang ^[9]

作者单位： Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China. ^[1] International Collaboration on Repair Discoveries (ICORD), Blusson Spinal Cord Centre, University of British Columbia, Vancouver, Canada. ^[2] The First School of Clinical Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China. ^[3] School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China. ^[4] Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. ^[5] Division of Spine Surgery, Department of Orthopaedics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, 51000, China. ^[6] The 3rd Affiliated Hospital of Xinxiang Medical University, Henan, China. ^[7] Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China. joehuang@smu.edu.cn. ^[8] Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China. jianghui@smu.edu.cn. ^[9]

关键词 CTSB (cathepsin B)Demyelination Lipid droplets Lipophagy MiR-223 Microglia