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SERPINB7 Deficiency Increases Legumain Activity and Impairs the Epidermal Barrier in Nagashima-Type Palmoplantar Keratoderma.

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作者: Siyuan,Li [1] ; Yingda,Wu [1] ; Dingfang,Bu [2] ; Linghan,Hu [1] ; Yihe,Liu [1] ; Juan,Liu [3] ; Ruiyu,Xiang [1] ; Wenbo,Bu [4] ; Ran,Mo [1] ; Zhongya,Song [1] ; Zhiming,Chen [1] ; Dongqing,Li [5] ; Xue,Zhang [6] ; Heng,Gu [4] ; Yong,Yang [7]
作者单位: Genetic Skin Disease Center, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Hospital for skin diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China. [1] Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, National Clinical Research Center for Skin and Immune Diseases, Beijing, China. [2] Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. [3] Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, China. [4] Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China. [5] McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China. [6] Genetic Skin Disease Center, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Hospital for skin diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China. Electronic address: yyang@pumcderm.cams.cn. [7]
DOI 10.1016/j.jid.2024.05.025
PMID 38909841
发布时间 2025-01-18
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The Journal of investigative dermatology

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