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Epigenetic modulators provide a path to understanding disease and therapeutic opportunity.

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第一作者： Madison A,Honer

第一单位： Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.;Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.;Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.;Biomedical Sciences Program, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania 19140, USA.

作者： Madison A,Honer ^[1] ; Benjamin I,Ferman ^[1] ; Zach H,Gray ^[1] ; Elena A,Bondarenko ^[2] ; Johnathan R,Whetstine ^[3]

作者单位： Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.;Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.;Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.;Biomedical Sciences Program, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania 19140, USA. ^[1] Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.;Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.;Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA. ^[2] Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA; johnathan.whetstine@fccc.edu.;Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.;Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA. ^[3]

关键词 DNA and histone modifications DNA methylation SWI/SNF acetylation bromodomain chromatin remodeling demethylase ecDNA epigenetics transcription

医学主题词后成说, 遗传(Epigenesis, Genetic);人类(Humans);动物(Animals);DNA甲基化(DNA Methylation);疾病(Disease)

DOI 10.1101/gad.351444.123

PMID 38914477

发布时间 2026-04-30

基金项目

P30 CA006927/CA/NCI NIH HHS/United States R35 GM144131/GM/NIGMS NIH HHS/United States T32 GM142606/GM/NIGMS NIH HHS/United States

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