Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS.

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第一作者： Hilal,Cihankaya

第一单位： Department of Cytology, Institute of Anatomy, Ruhr-University Bochum, 44801 Bochum, Germany.;International Graduate School of Neuroscience (IGSN), Ruhr-University Bochum, 44801 Bochum, Germany.

作者： Hilal,Cihankaya ^[1] ; Verian,Bader ^[2] ; Konstanze F,Winklhofer ^[3] ; Matthias,Vorgerd ^[4] ; Johann,Matschke ^[5] ; Sarah,Stahlke ^[6] ; Carsten,Theiss ^[1] ; Veronika,Matschke ^[1]

作者单位： Department of Cytology, Institute of Anatomy, Ruhr-University Bochum, 44801 Bochum, Germany.;International Graduate School of Neuroscience (IGSN), Ruhr-University Bochum, 44801 Bochum, Germany. ^[1] Department of Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Medical Faculty, Ruhr-University Bochum, 44801 Bochum, Germany. ^[2] International Graduate School of Neuroscience (IGSN), Ruhr-University Bochum, 44801 Bochum, Germany.;Department of Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Medical Faculty, Ruhr-University Bochum, 44801 Bochum, Germany. ^[3] Department of Neurology, Heimer Institute for Muscle Research, University Hospital Bergmannsheil, Ruhr-University Bochum, Buerkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. ^[4] Institute of Cell Biology (Cancer Research), University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany. ^[5] Department of Cytology, Institute of Anatomy, Ruhr-University Bochum, 44801 Bochum, Germany. ^[6]

关键词 NLRP3 inflammasome amyotrophic lateral sclerosis miR-223-3p motor neuron degeneration pyroptotic cell death wobbler mouse

主题词动物(Animals);肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);运动神经元(Motor Neurons);炎性体(Inflammasomes);小鼠(Mice);微RNAs(MicroRNAs);脊髓(Spinal Cord);疾病模型, 动物(Disease Models, Animal);神经变性(Nerve Degeneration);小神经胶质细胞(Microglia);小鼠, 近交C57BL(Mice, Inbred C57BL);半胱氨酸天冬氨酸蛋白酶1(Caspase 1)

DOI 10.3390/cells13120995

PMID 38920626

发布时间 2025-01-22

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Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS.

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